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Related Experiment Videos

Persistent fetal circulation. Neurodevelopmental outcome.

E J Sell, J A Gaines, C Gluckman

    American Journal of Diseases of Children (1960)
    |January 1, 1985
    PubMed
    Summary

    Persistent fetal circulation (PFC) can lead to long-term neurodevelopmental issues in children. Early auditory screening and monitoring neurologic status are crucial for identifying potential hearing loss and developmental delays in infants with PFC.

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    Area of Science:

    • Pediatrics
    • Neonatology
    • Developmental Neurology

    Background:

    • Persistent fetal circulation (PFC) is a critical condition in neonates.
    • Long-term neurodevelopmental outcomes for children with PFC require further investigation.
    • Identifying early risk factors for developmental issues in PFC patients is essential.

    Purpose of the Study:

    • To evaluate the long-term neurodevelopmental outcomes in children with a history of persistent fetal circulation (PFC).
    • To identify correlations between specific factors and the development of neurosensory hearing loss in this cohort.
    • To recommend early diagnostic strategies for hearing loss and developmental delays in infants with PFC.

    Main Methods:

    • A longitudinal follow-up study of forty children diagnosed with persistent fetal circulation (PFC).

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  • Clinical examinations including neurologic assessments and hearing evaluations were conducted one to four years post-diagnosis.
  • Correlation analysis was performed to identify factors associated with neurosensory hearing loss.

    • Main Results:

    • At follow-up, 40% of children with PFC were normal, while significant percentages exhibited neurosensory hearing loss (20%), neurologic abnormalities (15%), and speech impairments (7.5%).
    • Neurosensory hearing loss was correlated with maternal insulin-dependent diabetes, specific Brazelton scale findings (hand-to-mouth facility), and eight-month neurologic status.
    • Three children had clinically suspect speech, and one experienced a delay in motor development.

    Conclusions:

    • Children with a history of persistent fetal circulation (PFC) are at significant risk for long-term neurodevelopmental sequelae, particularly hearing loss.
    • Early identification of hearing loss can be improved by neonatal auditory behavioral response testing, eight-month neurologic assessments, and attention to parental concerns regarding speech development.
    • Neonatal and infancy auditory screening are strongly recommended for all infants experiencing PFC during the neonatal period.