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[Presynaptic autoregulation of dopamine release].
Fiziologicheskii Zhurnal SSSR Imeni I. M. Sechenova
|January 1, 1985
Summary
Presynaptic dopamine autoreceptors regulate dopamine release in the rat brain. Increased dopamine levels reduce dopamine release, a process blocked by haloperidol.
Area of Science:
- Neuroscience
- Neuropharmacology
Context:
- The neostriatum plays a crucial role in motor control and reward.
- Dopamine is a key neurotransmitter in the brain, involved in various functions.
Purpose:
- To investigate the existence and mechanism of dopamine release autoregulation in the rat neostriatum.
- To determine the role of presynaptic dopamine autoreceptors in this process.
Summary:
- In vivo experiments using local perfusion of the rat neostriatum demonstrated dopamine release autoregulation mediated by presynaptic dopamine autoreceptors.
- Increased extracellular dopamine (via exogenous dopamine or cocaine) reduced K+-induced release of 3H-dopamine.
- Haloperidol blocked this inhibitory effect, confirming the involvement of dopamine receptors.
- Perfusion with dopamine also decreased evoked potentials (EPs) in the neostriatum upon stimulation of the substantia nigra, indicating reduced dopamine release.
Impact:
- Provides evidence for a negative feedback mechanism controlling dopamine release in the nigrostriatal pathway.
- Highlights the importance of presynaptic dopamine autoreceptors in modulating dopaminergic neurotransmission.
- Offers insights into potential therapeutic targets for conditions involving dopamine dysregulation.