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NIMH Treatment of Depression Collaborative Research Program. Background and research plan.

I Elkin, M B Parloff, S W Hadley

Archives of General Psychiatry

|March 1, 1985

Summary

The National Institute of Mental Health (NIMH) Treatment of Depression Collaborative Research Program (TDCRP) evaluated cognitive behavior therapy and interpersonal psychotherapy for depression. This multisite study established a research framework for psychotherapy effectiveness.

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Area of Science:

Psychiatry and Mental Health Research
Clinical Psychology and Psychotherapy Studies
Collaborative Research Networks in Mental Health

Background:

The National Institute of Mental Health (NIMH) initiated the Treatment of Depression Collaborative Research Program (TDCRP).
This program represents a significant coordinated, multisite effort in psychotherapy research.
Established a standardized protocol for investigating depression treatments.

Purpose of the Study:

To investigate the effectiveness of brief psychotherapy interventions for outpatient depression.
To compare cognitive behavior therapy (CBT) and interpersonal psychotherapy (IPT) against other conditions.
To establish a robust research framework for future psychotherapy effectiveness studies.

Main Methods:

A multisite study employing an identical research protocol across three research sites.
Involved training experienced therapists in standardized cognitive behavior therapy, interpersonal psychotherapy, and pharmacotherapy.
Utilized a training/pilot phase followed by an ongoing outcome study.

Main Results:

The study established the feasibility and methodology for a large-scale, multisite psychotherapy trial.
Provided a foundation for comparing the efficacy of different therapeutic modalities in depression treatment.
Demonstrated the successful implementation of standardized training for psychotherapists across multiple sites.

Conclusions:

The TDCRP serves as a model for collaborative, multisite research in psychotherapy.
The program's findings contribute to understanding the comparative effectiveness of different depression treatments.
Highlights the importance of standardized protocols and therapist training in clinical research.