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Preparation of highly purified F-actin-depolymerizing factor of human serum

R Thorstensson, C Sterky, R Norberg

    European Journal of Biochemistry
    |March 15, 1985
    PubMed

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    Actin Filament Depolymerization01:19

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    Actin filaments (F-actin) are composed of actin subunits. The dissociation of actin monomers can occur from either end of F-actin. The rate of dissociation is faster from the minus-end or the pointed end, where the actin subunits exist with a bound ADP, together known as ADP-actin. The depolymerization of F-actin is aided by proteins, including the actin-depolymerizing factor (ADF) and cofilin family of proteins, gelsolin, and glia maturation factor (GMF).
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