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Updated: Feb 9, 2026

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Published on: May 16, 2013
Reduced mean platelet volume is associated with poor prognosis in esophageal cancer
Wenjie Shen1, Ming-Ming Cui2, Xin Wang2
1Department of Gynaecology and Obstetrics, First Affiliated Hospital of Chinese PLA General Hospital, Beijing 100048, China.
Background:
Esophageal cancer (EC) is the sixth most common cause of death from cancer. Altered mean platelet volume (MPV) levels were found in patients with malignancies.
Objective:
The present study investigated whether MPV can predict the survival in EC patients.
Mehtods:
The clinical data of 236 consecutive EC patients between January 2009 and December 2009 in our center were retrospectively analyzed. The overall survival rate was estimated using Kaplan-Meier method. Cox proportional hazards models were fitted to model the relationships between patient characteristics and prognosis.
Results:
Decreased MPV was significantly correlated with tumor location and tumor differentiation (p< 0.001). Moreover, survival analysis revealed that the overall survival of patients with MPV ⩽ 7.4 fL was significantly shorter than that of those with MPV > 7.4 fL. Multivariate analysis identified MPV as an independent poor prognostic factor for overall survival.
Conclusions:
Reduced MPV is associated with worse survival outcome in EC.
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