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Updated: Feb 9, 2026

Clinicopathological Analysis of miRNA Expression in Breast Cancer Tissues by Using miRNA In Situ Hybridization
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The clinicopathological and prognostic significances of Dkk3 expression in cancers: A bioinformatics analysis

Guan-Yu Chen, Hua-Chuan Zheng

    Cancer Biomarkers : Section a of Disease Markers
    |May 31, 2018
    PubMed
    Abstract

    Insights

    Dickkopf-3 (Dkk3) expression is elevated in several cancers, including gastric, breast, and ovarian. Dkk3 levels correlate with cancer progression and patient survival, suggesting its potential as a diagnostic marker.

    Area of Science:

    • Molecular oncology
    • Cancer biology
    • Biomarker discovery

    Background:

    • Dickkopf-3 (Dkk3) protein negatively regulates Wnt signaling pathways by inhibiting Wnt ligands (Wnt3a, Wnt5a) and LRP6, and interacting with βTrCP to suppress the Wnt/β-catenin pathway.
    • Aberrant Wnt signaling is implicated in various cancers.

    Purpose of the Study:

    • To investigate the expression patterns of Dkk3 mRNA in different cancer types.
    • To analyze the correlation between Dkk3 expression and clinicopathological features and patient survival.

    Main Methods:

    • Bioinformatics analysis of Dkk3 mRNA expression using Oncomine, TCGA, and Kaplan-Meier plotter databases.
    • Data analysis included comparisons across various cancer types, subtypes, and patient demographics.

    Main Results:

    • Dkk3 expression was significantly higher in gastric, breast, and ovarian cancers compared to normal tissues.
    • Specific cancer subtypes, such as ovarian cytoadenocarcinoma and ductal breast cancer, showed higher Dkk3 levels.
    • Dkk3 expression was negatively correlated with overall survival in gastric, breast, and ovarian cancers, but positively correlated in lung cancer.

    Conclusions:

    • Dkk3 expression may serve as a potential biomarker for cancer diagnosis, indicating carcinogenesis and histogenesis.
    • Dkk3 levels could be a prognostic indicator for patient outcomes in several cancer types.
    Keywords:
    Dkk3aggressivenessbioinformatics analysiscarcinogenesisprognosis

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