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Effect of probiotics on C-reactive protein levels in preterm infants: Secondary analysis of a randomized controlled

S Agrawal1,2,3, S Rao1,2,3, E A Nathan4,5

  • 1Department of Neonatal Paediatrics, KEM Hospital, Perth, WA, Australia.

Journal of Neonatal-Perinatal Medicine
|May 31, 2018
PubMed

Insights

Bifidobacterium breve m-16v did not significantly alter C-reactive protein (CRP) levels in preterm infants. This study found no evidence that probiotics reduce inflammation markers in this vulnerable population.

Area of Science:

  • Neonatal Medicine
  • Microbiology
  • Immunology

Background:

  • Excessive inflammation in preterm infants is linked to poor outcomes.
  • C-reactive protein (CRP) is a key indicator of inflammation and infection.
  • Probiotics are known for their anti-inflammatory potential, but their effect on CRP in preterm infants remains under-researched.

Purpose of the Study:

  • To investigate the impact of Bifidobacterium breve (B. breve) m-16v supplementation on CRP levels in preterm infants.
  • To analyze CRP data from a randomized controlled trial (RCT) involving preterm infants.

Main Methods:

  • Analysis of data from 159 preterm infants (gestational age <33 weeks) participating in an RCT.
  • Defined normal CRP levels as <15 mg/L in the first week and ≤10 mg/L thereafter.
  • Employed mixed logistic regression to assess the effect of probiotics on CRP.

Main Results:

  • A total of 1579 CRP measurements were analyzed (851 in the probiotic group, 728 in the placebo group).
  • No significant difference was observed in the proportion of infants with elevated CRP over time or across all time points between the probiotic and placebo groups (adjusted OR: 1.62, 95% CI: 0.91-2.88).

Conclusions:

  • Bifidobacterium breve m-16v supplementation did not lead to a decrease in CRP levels in preterm infants born before 33 weeks gestation.
  • The findings suggest that this specific probiotic strain may not be effective in modulating inflammatory markers like CRP in this population.
Abstract

Keywords:
Bifidobacterium breveC-reactive proteininflammationpreterm infantprobiotic

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