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Childhood infectious diseases and risk of multiple myeloma: an analysis of the Italian multicentre case-control study

E Stagnaro1, S Parodi2, A Seniori Costantini3

  • 1Clinical Epidemiology,Ospedale Policlinico San Martino, IRCCS,Genoa,Italy.

Epidemiology and Infection
|May 31, 2018
PubMed

Insights

Childhood infections like chickenpox, measles, and mumps do not appear to reduce the risk of developing multiple myeloma (MM). This study found no significant link between common childhood diseases and a lower risk of MM.

Area of Science:

  • Epidemiology
  • Oncology
  • Immunology

Background:

  • Childhood infectious diseases are linked to lower risks of some cancers.
  • Research on the association between common childhood infections and multiple myeloma (MM) risk is limited.

Purpose of the Study:

  • To investigate the association between common childhood infectious diseases and the risk of developing multiple myeloma (MM).

Main Methods:

  • A multicentre population-based case-control study was conducted in Italy.
  • Data from 213 MM cases and 1128 healthy controls were analyzed.
  • Unconditional logistic regression was used to estimate the association, adjusting for age, gender, and residence.

Main Results:

  • No significant association was found between individual childhood infectious diseases (chickenpox, measles, mumps, pertussis, rubella) and MM risk.
  • A slight, non-significant inverse association was observed between the number of infections and MM risk (OR 0.68 for 3-5 diseases vs. none).

Conclusions:

  • Common childhood infections do not appear to be associated with a reduced risk of developing multiple myeloma (MM).
  • Further research may be needed to explore potential complex interactions or different infectious agents.
Keywords:
case-control studychickenpoxchildhood infectionsmeaslesmultiple myelomamumpspertussisrubella

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