Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

6.4K
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
6.4K
Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment01:08

Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment

281
Hepatic impairment, characterized by decreased liver function, does not uniformly mandate adjustments in drug dosage. Whether dosage modifications are necessary depends on various factors related to the drug's metabolism and elimination pathways. If a drug is primarily excreted via the kidneys and bypasses significant hepatic processing, if it undergoes minimal metabolic transformation in the liver, or if it is volatile and primarily expelled through the lungs, dose adjustments may not be...
281
Hepatic Portal System01:21

Hepatic Portal System

6.1K
The hepatic portal system, a critical part of our circulatory framework, transports nutrient-laden, deoxygenated blood from the gastrointestinal tract and spleen to the liver. This ingenious system plays an indispensable role in maintaining our body's metabolic equilibrium.
At its core, the hepatic portal vein is the result of a confluence of the superior and inferior mesenteric veins along with the splenic vein. Each of these veins has a unique role. The superior mesenteric vein is...
6.1K
Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow01:26

Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow

248
Chronic liver disease significantly impacts drug metabolism due to alterations in hepatic blood flow and enzyme accessibility. This disruption affects the body's pharmacokinetics—the movement and processing of drugs within the system. Key enzymes crucial for metabolizing medications become less accessible, changing how drugs are processed and utilized. Furthermore, liver disease influences the synthesis of plasma proteins, such as albumin and globulins, which play critical roles in drug...
248
Hepatic Drug Excretion: Influencing Factors01:16

Hepatic Drug Excretion: Influencing Factors

597
The biliary system of the liver, crucial for bile secretion and drug excretion, comprises intrahepatic bile ducts that merge to form the common hepatic duct. This duct, carrying hepatic bile, combines with the cystic duct, draining the gallbladder and forming the common bile duct, which empties into the duodenum. Bile, produced by hepatic cells lining the bile canaliculi, is composed primarily of water, bile salts, pigments, electrolytes, and lesser amounts of cholesterol and fatty acids. Bile...
597
Hepatic Drug Clearance: Role of Transporters01:14

Hepatic Drug Clearance: Role of Transporters

311
In the liver and bile canaliculi, influx and efflux transporters modification can influence intrinsic clearance. Transporters play a significant role in moving drugs within liver cells. Elaborate models, such as the Biopharmaceutical Classification System (BCS), are essential to relate transporters to drug disposition. This system categorizes drugs into four classes based on solubility and permeability, providing insights into elimination routes and the effects of transporters following oral...
311

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Consensus Statement from the Society of Gynecologic Oncology of Canada on Folate Receptor α Testing in Ovarian Cancer.

Current oncology (Toronto, Ont.)·2026
Same author

Epigenetic control of telomeric RNA maintains heterochromatin in telomerase-driven cancers.

Signal transduction and targeted therapy·2026
Same author

Insights into the therapeutic targeting of ASIC3 in pain: hurdles for clinical development.

Expert opinion on therapeutic targets·2026
Same author

Valorization of baghouse dust from lime industry through carbonation processes.

Waste management (New York, N.Y.)·2026
Same author

Knowledge, attitudes, and practices toward food allergies among early childhood educators in Taiwan: a cross-sectional study.

Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology·2026
Same author

Airway microbial dysbiosis and oxidative mitochondrial DNA damage in the development of bronchopulmonary dysplasia.

ERJ open research·2026
Same journal

Cuproptosis-mediated metabolic-inflammatory coupling in hypertensive myocardial injury: Mechanistic insights and therapeutic perspectives.

Pathology, research and practice·2026
Same journal

COL6A3 drives tumor progression and predicts prognosis in cervical squamous cell carcinoma.

Pathology, research and practice·2026
Same journal

A novel oxygen-releasing bilayer delivery system for cell survival and peripheral nerve regeneration.

Pathology, research and practice·2026
Same journal

Autophagy modulation in ulcerative colitis with traditional Chinese medicine: A review.

Pathology, research and practice·2026
Same journal

Ras signalling in infectious disease pathology: Mechanisms, tissue damage, and clinical implications.

Pathology, research and practice·2026
Same journal

CBFβ-SMMHC in inv(16) AML: Fusion biology, RUNX1 dysregulation, and therapeutic targeting of a leukemogenic protein-protein interaction.

Pathology, research and practice·2026
See all related articles

Related Experiment Video

Updated: Feb 9, 2026

Isolation of Human Endometrial Stromal Cells for In Vitro Decidualization
14:55

Isolation of Human Endometrial Stromal Cells for In Vitro Decidualization

Published on: September 1, 2018

11.1K

Hepatic endometrial stromal sarcoma.

Nick Baniak1, Scott Adams2, Rajni Chibbar1

  • 1Department of Pathology and Laboratory Medicine, College of Medicine, University of Saskatchewan, Saskatoon, Canada.

Pathology, Research and Practice
|May 31, 2018
PubMed
Summary
This summary is machine-generated.

Endometrial stromal sarcoma (ESS) can metastasize distantly, though liver metastasis is exceptionally rare. This report details two such rare cases, offering insights into this uncommon presentation of ESS.

Keywords:
Endometrial stromal sarcomaExtra-pelvicJAZF1-SUZ12 rearrangementMetastases

More Related Videos

Isolation of Mouse Endometrial Epithelial and Stromal Cells for In Vitro Decidualization
08:37

Isolation of Mouse Endometrial Epithelial and Stromal Cells for In Vitro Decidualization

Published on: March 2, 2017

25.6K
Two Methods for Establishing Primary Human Endometrial Stromal Cells from Hysterectomy Specimens
09:15

Two Methods for Establishing Primary Human Endometrial Stromal Cells from Hysterectomy Specimens

Published on: May 23, 2014

23.7K

Related Experiment Videos

Last Updated: Feb 9, 2026

Isolation of Human Endometrial Stromal Cells for In Vitro Decidualization
14:55

Isolation of Human Endometrial Stromal Cells for In Vitro Decidualization

Published on: September 1, 2018

11.1K
Isolation of Mouse Endometrial Epithelial and Stromal Cells for In Vitro Decidualization
08:37

Isolation of Mouse Endometrial Epithelial and Stromal Cells for In Vitro Decidualization

Published on: March 2, 2017

25.6K
Two Methods for Establishing Primary Human Endometrial Stromal Cells from Hysterectomy Specimens
09:15

Two Methods for Establishing Primary Human Endometrial Stromal Cells from Hysterectomy Specimens

Published on: May 23, 2014

23.7K

Area of Science:

  • Gynecologic Oncology
  • Pathology
  • Medical Research

Background:

  • Endometrial stromal sarcoma (ESS) is a rare uterine malignancy.
  • ESS has a propensity for late recurrence and distant metastasis, commonly to the lungs.
  • Liver metastasis from ESS is exceedingly uncommon.

Observation:

  • This report presents two unique cases of endometrial stromal sarcoma (ESS) with liver metastases.
  • Neither patient had a history of endometriosis.
  • Histology, immunohistochemistry, and molecular analyses were performed.

Findings:

  • Confirmed liver metastases in two patients with endometrial stromal sarcoma (ESS).
  • Demonstrated the possibility of ESS liver metastasis without prior endometriosis.
  • Detailed clinicopathological and molecular features of these rare cases.

Implications:

  • Highlights the potential for rare metastatic patterns in endometrial stromal sarcoma (ESS).
  • Underscores the importance of considering ESS in the differential diagnosis of liver lesions, even without a history of endometriosis.
  • Contributes to the understanding of ESS behavior and informs potential diagnostic and therapeutic strategies.