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Updated: Feb 9, 2026

Sample Preparation for Endopeptidomic Analysis in Human Cerebrospinal Fluid
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Cerebrospinal Fluid Protein Changes in Preeclampsia.

Erin Ciampa1, Yunping Li1, Simon Dillon2,3

  • 1From the Departments of Anesthesia (E.C., Y.L., L.S., P.E.H.).

Hypertension (Dallas, Tex. : 1979)
|May 31, 2018
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Summary

Altered cerebrospinal fluid (CSF) proteins in preeclampsia may explain neurological symptoms. Key signaling pathways involved in vascular remodeling and neuronal function were identified, offering new insights into severe preeclampsia pathogenesis.

Keywords:
activinbraincerebrospinal fluid proteinshypertensionpreeclampsiaproteomics

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Area of Science:

  • Neuroscience
  • Proteomics
  • Obstetrics

Background:

  • Preeclampsia is a pregnancy complication associated with neurological symptoms like seizures.
  • The underlying molecular mechanisms in the central nervous system remain largely unknown.

Purpose of the Study:

  • To investigate differences in cerebrospinal fluid (CSF) protein expression in patients with severe preeclampsia compared to controls.
  • To identify potential biomarkers and signaling pathways contributing to neurological manifestations.

Main Methods:

  • CSF samples were collected from 13 preeclampsia patients and 14 controls.
  • Aptamer-based proteomics (SOMAscan) analyzed 1310 protein levels.
  • Pathway analysis and ELISA validation were performed.

Main Results:

  • 82 proteins showed significantly different expression levels in preeclampsia CSF.
  • Differentially expressed proteins were associated with TGF-β, VEGFA, angiotensinogen, and IL-6 signaling pathways.
  • Upregulation of activin A and follistatin-related gene was confirmed by ELISA.

Conclusions:

  • Altered protein expression in CSF reflects central nervous system changes in preeclampsia.
  • Identified pathways are crucial for vascular remodeling, inflammation, and neuronal function.
  • These findings may contribute to understanding and managing neurological complications of preeclampsia.