Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Mixed-function oxidase system induction and propylene hepatotoxicity.

T G Osimitz, R B Conolly

    Journal of Toxicology and Environmental Health
    |January 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Risk assessment from potential exposure to tetrabromobisphenol A (TBBPA) from its use in electronics.

    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association·2025
    Same author

    Perspectives on safety of quaternary ammonium compounds (QACs).

    Journal of toxicology and environmental health. Part B, Critical reviews·2025
    Same author

    Adverse Outcome Pathway for Antimicrobial Quaternary Ammonium Compounds.

    Journal of toxicology and environmental health. Part A·2022
    Same author

    Post-market surveillance of consumer products: Framework for adverse event management.

    Regulatory toxicology and pharmacology : RTP·2021
    Same author

    Adverse events associated with the use of insect repellents containing N,N-diethyl-m-toluamide (DEET).

    Regulatory toxicology and pharmacology : RTP·2009
    Same author

    Nonlinearity and thresholds in dose-response relationships for carcinogenicity due to sampling variation, logarithmic dose scaling, or small differences in individual susceptibility.

    Toxicology and applied pharmacology·2005
    Same journal

    Pharmacokinetics of TCDD in veterans of Operation Ranch Hand: 10-year follow-up.

    Journal of toxicology and environmental health·1998
    Same journal

    Alterations of male Wistar rat jejunum induced by Dodine (n-dodecylguanidine acetate).

    Journal of toxicology and environmental health·1997
    Same journal

    Cadmium toxicity and distribution in metallothionein-I and -II deficient transgenic mice.

    Journal of toxicology and environmental health·1997
    Same journal

    Comparison of the binding potential of various diisocyanates on DNA in vitro.

    Journal of toxicology and environmental health·1997
    Same journal

    Investigation of the potential impact of benchmark dose and pharmacokinetic modeling in noncancer risk assessment.

    Journal of toxicology and environmental health·1997
    Same journal

    Effect of cypermethrin on isolated male and female rat hepatocytes.

    Journal of toxicology and environmental health·1997
    See all related articles

    Polychlorinated biphenyls (PCB) pretreatment is necessary for propylene to cause liver damage in rats. Propylene exposure depletes cytochrome P-450, indicating a bioactivation mechanism linked to PCB-induced hepatotoxicity.

    Area of Science:

    • Toxicology
    • Biochemistry
    • Pharmacology

    Background:

    • Polychlorinated biphenyls (PCB) are known environmental contaminants.
    • Propylene is a common industrial chemical.
    • Understanding chemical interactions with biological systems is crucial for safety.

    Purpose of the Study:

    • To investigate the hepatotoxicity of propylene in rats pretreated with PCBs.
    • To explore the role of cytochrome P-450 in propylene-induced liver injury.
    • To differentiate the mechanisms of PCB-induced and other forms of propylene toxicity.

    Main Methods:

    • Rats were pretreated with Aroclor 1254 (PCB), beta-naphthoflavone (BNF), or phenobarbital (PB).
    • Animals were exposed to propylene via inhalation.
    • Liver weight/body weight ratios, serum enzyme activities, and hepatic microsomal cytochrome P-450 levels and enzyme activities were measured.

    Related Experiment Videos

    Main Results:

    • Propylene exposure (50,000 ppm) caused hepatotoxicity in PCB-pretreated rats, indicated by increased liver weight/body weight ratios and elevated serum enzymes.
    • PCB-pretreated rats showed a significant decrease in hepatic microsomal cytochrome P-450 content and aniline hydroxylase activity.
    • Rats pretreated with BNF or PB did not exhibit hepatotoxicity, but still showed a decline in cytochrome P-450 levels.
    • SKF-525A administration prevented propylene-induced hepatotoxicity in PCB-pretreated rats.
    • In vitro studies confirmed NADPH-dependent cytochrome P-450 decrease with propylene exposure.

    Conclusions:

    • PCB pretreatment is a prerequisite for propylene-induced hepatotoxicity in rats.
    • Cytochrome P-450-dependent bioactivation of propylene is associated with this hepatotoxicity.
    • The mechanism of PCB-propylene interaction requires further investigation.