Short-term increase in discs' apparent diffusion is associated with pain and mobility improvements after spinal...

Pain perception, trunk mobility and apparent diffusion coefficient (ADC) within all lumbar intervertebral discs (IVDs) were collected before and shortly after posterior-to-anterior (PA) mobilizations in 16 adults with acute low back pain. Using a pragmatic approach, a trained orthopaedic manual physical therapist applied PA mobilizations to the participants' spine, in accordance with his examination findings. ADC _all was computed from diffusion maps as the mean of anterior (ADC _ant ), middle (ADC _mid ), and posterior (ADC _post ) portions of the IVD. After mobilization, pain ratings and trunk mobility were significantly improved and a significant increase in ADC _all values was observed. The greatest ADC _all changes were observed at the L₃-L₄ and L₄-L₅ levels and were mainly explained by changes in ADC _ant and ADC _post , respectively. No significant changes in ADC were observed at L₅-S₁ level. The reduction in pain and largest changes in ADC observed at the periphery of the hyperintense IVD region suggest that increased peripheral random motion of water molecules is implicated in the IVD nociceptive response modulation. Additionally, ADC changes were observed at remote IVD anatomical levels that did not coincide with the PA spinal mobilization application level.