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NDRG3 facilitates colorectal cancer metastasis through activating Src phosphorylation

Ting Li1, Ruochuan Sun1, Mingdian Lu1

  • 1Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, He Fei, 230222, China.

Oncotargets and Therapy
|May 31, 2018
PubMed
Abstract

Insights

NDRG3 promotes colorectal cancer (CRC) migration and invasion by activating Src phosphorylation. This finding suggests NDRG3 acts as a potential oncogene in CRC progression.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • NDRG3 (N-myc downregulated gene 3) is a gene implicated in cancer development.
  • Its specific role and mechanism in colorectal cancer (CRC) require elucidation.

Purpose of the Study:

  • To investigate the function of NDRG3 in colorectal cancer (CRC).
  • To determine the underlying molecular mechanisms driving NDRG3's role in CRC progression.

Main Methods:

  • Analyzed NDRG3 expression in 170 CRC samples using immunohistochemistry.
  • Manipulated NDRG3 levels in CRC cell lines (SW1116 and RKO) to assess migration and invasion.
  • Utilized in vitro and in vivo (mouse model) experiments to evaluate metastasis.

Main Results:

  • Elevated NDRG3 expression in CRC tissues correlated with distant metastasis.
  • NDRG3 overexpression enhanced CRC cell migration and invasion; NDRG3 knockdown suppressed these processes.
  • NDRG3 facilitated liver metastasis, linked to Src phosphorylation at Tyr 419.

Conclusions:

  • NDRG3 promotes CRC cell migration and invasion through Src activation.
  • NDRG3 is identified as a potential oncogene in colorectal cancer.
Keywords:
NDRG3Srccolorectal cancermetastasis

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