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Updated: Feb 9, 2026

Quantitative Measurement of GLUT4 Translocation to the Plasma Membrane by Flow Cytometry
Published on: November 7, 2010
Diagnostic and treatment hurdles in plasma cell myeloma with t(11;14) translocation: A case report
Shun Yin Kong1, Wing Kit Lam2, Ka Shu Li1
1Department of Medicine and Geriatrics, Tuen Mun Hospital, Hong Kong, SAR 999077, P.R. China.
Abstract:
t(11;14) translocation is one of the most common chromosomal abnormalities in plasma cell myeloma. The present case report presented a case of plasma cell myeloma with t(11;14) translocation, in which the plasma cells were small lymphoplasmacytoids in morphology with positive cluster of differentiation-20 and Cyclin D1 expression. These results led to initial diagnostic difficulties. The patient was refractory to bortezomib-based therapy, and responsive to vincristine, doxorubicin and dexamethasone. However, the prognostic value of t(11;14) in plasma cell myeloma remains to be determined. With recent advances in treatment options, physicians should be aware of the clinical and pathological characteristics of this translocation in plasma cell myeloma.
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