Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Nucleosome Core Particle02:10

The Nucleosome Core Particle

14.6K
Nucleosomes are the DNA-histone complex, where the DNA strand is wound around the histone core. The histone core is an octamer containing two copies of H2A, H2B, H3, and H4 histone proteins.
The paradox
Nucleosomes, paradoxically, perform two opposite functions simultaneously. On the one hand, their main responsibility is to protect the delicate DNA strands from physical damage and help achieve a higher compaction ratio. While on the other hand, they must allow polymerase enzymes to access DNA...
14.6K
The Nucleosome Core Particle01:12

The Nucleosome Core Particle

2.4K
Nucleosomes are the DNA-histone complex, where the DNA strand is wound around the histone core. The histone core is an octamer containing two copies of H2A, H2B, H3, and H4 histone proteins.
Nucleosomes, paradoxically, perform two opposite functions simultaneously. On the one hand, their primary aim is to protect the delicate DNA strands from physical damage and help achieve a higher compaction ratio. On the other hand, they must allow polymerase enzymes to access histone-bound DNA during...
2.4K
The Carbon Cycle01:14

The Carbon Cycle

44.0K
Carbon is the basis of all organic matter on Earth, and is recycled through the ecosystem in two primary processes: one in which carbon is exchanged among living organisms, and one in which carbon is cycled over long periods of time through fossilized organic remains, weathering of rocks, and volcanic activity. Human activities, including increased agricultural practices and the burning of fossil fuels, has greatly affected the balance of the natural carbon cycle.
44.0K
Carbon Skeletons01:12

Carbon Skeletons

115.4K
Life on Earth is carbon-based, as all macromolecules that make up living organisms contain carbon atoms. All organic compounds have a carbon backbone. Each carbon atom is tetravalent and can bond with four other atoms, making it an extraordinarily flexible component of biological molecules. Because carbon’s valence electrons are stable, it rarely becomes an ion. As the carbon chain increases in length, structural modifications such as ring structures, double bonds, and branching side...
115.4K
Carbonation Shrinkage01:24

Carbonation Shrinkage

498
Atmospheric CO2 penetrates the concrete's pores and, in the presence of moisture, forms carbonic acid, which then reacts with calcium hydroxide in the hydrated cement, forming calcium carbonate. This process reduces the concrete's volume and is termed carbonation shrinkage.
The concrete's permeability is slightly reduced as calcium carbonate produced during the reaction fills its pores. Furthermore, its strength is slightly enhanced as the water released during the reaction...
498
Pinching-off of Coated Vesicles01:32

Pinching-off of Coated Vesicles

4.2K
Vesicle budding is orchestrated by distinct cytosolic proteins such as adaptor proteins, coat proteins, and GTPases. To initiate vesicle budding, membrane-bending proteins containing crescent-shaped BAR domains bind to the lipid heads in the bilayer and distort the membrane to form a protein-coated vesicle bud. Adaptors proteins such as AP2 for clathrin-coated vesicles can nucleate on the deformed membrane. Finally, coat proteins such as clathrin or COPI and COPII assemble into a coat forming...
4.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Inflammatory biomarkers and sarcopenia in older adults.

Frontiers in aging·2026
Same author

Delirium in older hospitalized patients: a decade-later study highlighting medical and medication-related etiologies beyond muscarinic antagonism.

Naunyn-Schmiedeberg's archives of pharmacology·2026
Same author

Temporal-Compositional Engineering of Manganese Ferrite Nanoparticles for Tunable Theranostic Performance.

Langmuir : the ACS journal of surfaces and colloids·2026
Same author

Implementation of a Bedside Percutaneous Dilatational Tracheostomy Program in a Pulmonary and Critical Care Fellowship: Enhancing Patient Safety with a Checklist.

Journal of intensive care medicine·2026
Same author

Barriers and facilitators to advance care planning implementation for patients with neurodegenerative diseases among Indian physicians: a mixed-methods analysis.

BMC health services research·2026
Same author

Diagnostic Utility of Extended Focused Assessment With Sonography in Trauma (eFAST) in Hemodynamically Stable Patients With Blunt Thoracoabdominal Injury: A Prospective Study.

Cureus·2026

Related Experiment Video

Updated: Feb 9, 2026

Polyethyleneimine-coated Iron Oxide Nanoparticles as a Vehicle for the Delivery of Small Interfering RNA to Macrophages In Vitro and In Vivo
09:36

Polyethyleneimine-coated Iron Oxide Nanoparticles as a Vehicle for the Delivery of Small Interfering RNA to Macrophages In Vitro and In Vivo

Published on: February 5, 2019

9.4K

Carbon coated core-shell multifunctional fluorescent SPIONs.

Ashish Tiwari1, Navneet C Verma, Anup Singh

  • 1School of Engineering, Indian Institute of Technology Mandi, Mandi, Himachal Pradesh, India. jaspreet@iitmandi.ac.in.

Nanoscale
|May 31, 2018
PubMed
Summary
This summary is machine-generated.

Researchers developed novel carbon-coated superparamagnetic iron oxide nanoparticles (SPIONs) for multimodal bioimaging. These non-toxic SPIONs offer long-lasting fluorescence and superior magnetic resonance imaging capabilities, overcoming limitations of previous probes.

More Related Videos

Synthesis and Operation of Fluorescent-core Microcavities for Refractometric Sensing
08:12

Synthesis and Operation of Fluorescent-core Microcavities for Refractometric Sensing

Published on: March 13, 2013

13.2K
Graphene Coatings for Biomedical Implants
13:21

Graphene Coatings for Biomedical Implants

Published on: March 1, 2013

21.8K

Related Experiment Videos

Last Updated: Feb 9, 2026

Polyethyleneimine-coated Iron Oxide Nanoparticles as a Vehicle for the Delivery of Small Interfering RNA to Macrophages In Vitro and In Vivo
09:36

Polyethyleneimine-coated Iron Oxide Nanoparticles as a Vehicle for the Delivery of Small Interfering RNA to Macrophages In Vitro and In Vivo

Published on: February 5, 2019

9.4K
Synthesis and Operation of Fluorescent-core Microcavities for Refractometric Sensing
08:12

Synthesis and Operation of Fluorescent-core Microcavities for Refractometric Sensing

Published on: March 13, 2013

13.2K
Graphene Coatings for Biomedical Implants
13:21

Graphene Coatings for Biomedical Implants

Published on: March 1, 2013

21.8K

Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Nanotechnology

Background:

  • Superparamagnetic iron oxide nanoparticles (SPIONs) are promising for magnetic resonance (MR) imaging due to their magnetic properties and biocompatibility.
  • Current SPIONs lack fluorescence, hindering multimodal bioimaging applications.
  • Existing fluorescent SPIONs using organic dyes or quantum dots (QDs) suffer from poor photostability, photobleaching, or toxicity.

Purpose of the Study:

  • To develop a novel, non-toxic, core-shell SPION with both magnetic and fluorescent properties.
  • To create a highly photostable fluorescent probe for long-term multimodal bioimaging.
  • To enhance SPIONs for superior magnetic resonance imaging alongside fluorescence.

Main Methods:

  • A one-step synthesis method was employed to create carbon-coated SPIONs.
  • The core-shell nanoparticles were engineered to possess both magnetic and fluorescent characteristics.
  • Characterization focused on magnetic properties, fluorescence stability, and biocompatibility.

Main Results:

  • The synthesized SPIONs exhibit excellent superparamagnetic properties comparable to existing agents.
  • The carbon coating provides highly photostable, long-lasting fluorescence, outperforming Rhodamine and cyanine dyes.
  • The novel SPIONs demonstrate superior performance for multimodal bioimaging and MR imaging.

Conclusions:

  • The developed carbon-coated SPIONs offer a non-toxic, stable, and effective solution for multimodal bioimaging.
  • These nanoparticles overcome the limitations of photobleaching and toxicity associated with previous fluorescent probes.
  • The enhanced magnetic and optical properties position these SPIONs as valuable tools in biomedical applications.