Related Experiment Video

Updated: Aug 10, 2026

Oncogenic Gene Fusion Detection Using Anchored Multiplex Polymerase Chain Reaction Followed by Next Generation Sequencing
09:49

Oncogenic Gene Fusion Detection Using Anchored Multiplex Polymerase Chain Reaction Followed by Next Generation Sequencing

Published on: July 5, 2019

Oncogenes. A possible role for cancer genes in human malignant disease

M Haber, B W Stewart

    The Medical Journal of Australia
    |April 1, 1985
    PubMed

    Insights

    Normal cellular oncogenes can cause cancer when activated by specific mechanisms. These genes are crucial for normal cell growth but can lead to uncontrolled proliferation and malignant transformation.

    Area of Science:

    • Molecular Biology
    • Oncology
    • Genetics

    Background:

    • Normal cellular genes, known as cellular oncogenes, possess the potential for malignant cell transformation.
    • These genes share similarities with transforming genes found in oncogenic RNA viruses (retroviruses).
    • Cellular oncogenes are integral to normal cellular processes, particularly growth regulation, and are not inherently tumorigenic.

    Purpose of the Study:

    • To review the evidence implicating cellular oncogenes in human malignant diseases.
    • To explore the mechanisms by which cellular oncogenes become malignantly activated.
    • To understand the role of cellular oncogenes in uncontrolled cellular proliferation.

    Main Methods:

    • Comparative analysis of cellular oncogenes and viral transforming genes.
    • Investigation of gene transfer experiments to assess cellular transformation.
    • Review of existing literature and evidence linking oncogenes to human cancers.

    Main Results:

    • Cellular oncogenes can induce malignant transformation under specific conditions.
    • Multiple mechanisms exist for the aberrant activation of cellular oncogenes.
    • Evidence strongly implicates cellular oncogenes in the development of human cancers.

    Conclusions:

    • Cellular oncogenes play a critical role in the pathogenesis of human malignant diseases.
    • Understanding oncogene activation is key to developing cancer therapies.
    • Further research into oncogene regulation is essential for cancer prevention and treatment.

    More Related Videos

    Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells09:37

    Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells

    Published on: August 25, 2021

    Oncogene Expression Analysis with Alterations in pH in a Pancreatic Ductal Cell Line06:24

    Oncogene Expression Analysis with Alterations in pH in a Pancreatic Ductal Cell Line

    Published on: April 11, 2025

    Related Concept Videos

    Cancers Originate from Somatic Mutations in a Single Cell02:21

    Cancers Originate from Somatic Mutations in a Single Cell

    Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
    Cancer-Critical Genes I: Proto-oncogenes01:33

    Cancer-Critical Genes I: Proto-oncogenes

    Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
    When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
    Such genes that act...
    Cancer-Critical Genes II: Tumor Suppressor Genes01:05

    Cancer-Critical Genes II: Tumor Suppressor Genes

    Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
    When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
    Such genes that act...
    Cancers Originate from Somatic Mutations in a Single Cell02:21

    Cancers Originate from Somatic Mutations in a Single Cell

    Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
    Cancer-Critical Genes I: Proto-oncogenes01:33

    Cancer-Critical Genes I: Proto-oncogenes

    Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
    When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
    Such genes that act...
    Cancer-Critical Genes II: Tumor Suppressor Genes01:05

    Cancer-Critical Genes II: Tumor Suppressor Genes

    Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
    When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
    Such genes that act...