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Dispersion of Nanomaterials in Aqueous Media: Towards Protocol Optimization
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Curcumin-loaded self-nanomicellizing solid dispersion system: part I: development, optimization, characterization,

Ankit Parikh1, Krishna Kathawala1, Yunmei Song1

  • 1School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, SA, 5000, Australia.

Drug Delivery and Translational Research
|May 31, 2018
PubMed
Summary
This summary is machine-generated.

A novel curcumin formulation (NCF) significantly enhances oral bioavailability by improving solubility and stability. This self-nanomicellizing solid dispersion strategy offers a promising approach for curcumin

Keywords:
CurcuminOral bioavailabilityPermeabilitySolubilitySoluplusStability

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Area of Science:

  • Pharmacology and Pharmaceutical Sciences
  • Materials Science
  • Biochemistry

Background:

  • Curcumin (CUR) exhibits potent anti-inflammatory and antioxidant properties.
  • Poor oral bioavailability limits the clinical application of CUR.
  • Enhancing CUR's solubility, stability, and permeability is crucial for therapeutic development.

Purpose of the Study:

  • To develop a novel curcumin formulation (NCF) with enhanced oral bioavailability.
  • To investigate the potential of self-nanomicellizing solid dispersion strategy for CUR delivery.
  • To evaluate the impact of Soluplus (SOL) polymer on CUR formulation properties.

Main Methods:

  • Development of NCF using self-nanomicellizing solid dispersion with Soluplus (SOL).
  • Characterization of NCF using techniques like DSC, XRD, SEM, FTIR, NMR, DLS, and TEM.
  • Assessment of CUR solubility, stability, dissolution, and intestinal permeability.
  • Pharmacokinetic studies comparing NCF, physical mixture, and CUR suspension.

Main Results:

  • NCF achieved over 20,000-fold improvement in aqueous solubility.
  • NCF demonstrated enhanced stability in alkaline pH and light conditions.
  • Significant increases in CUR dissolution and intestinal permeability were observed with NCF.
  • Oral bioavailability of CUR increased 117-fold with NCF and 17-fold with a physical mixture.

Conclusions:

  • NCF is a promising formulation for enhancing curcumin's oral bioavailability.
  • The self-nanomicellizing solid dispersion strategy effectively overcomes CUR's bioavailability limitations.
  • NCF warrants further in vivo and clinical evaluation for pharmaceutical applications.