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Updated: Feb 9, 2026
A Multimodal Imaging Framework to Advance Phenotyping of Living Label-free Breast Cancer Cells
Published on: August 22, 2025
Applications of Advanced Breast Imaging Modalities
Arwa A Alzaghal1,2, Pamela J DiPiro3,4
1Department of Imaging, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA, 02215, USA.
Digital breast tomosynthesis (DBT) reduces recalls and slightly increases cancer detection. However, supplemental imaging like MRI and ultrasound offer superior sensitivity, especially for high-risk patients with dense breasts.
Area of Science:
- Radiology
- Medical Imaging
- Oncology
Background:
- Advanced mammographic imaging, including digital breast tomosynthesis (DBT), is increasingly used in the USA.
- DBT is a 3D derivative of digital mammography.
Purpose of the Study:
- To review the screening and diagnostic applications of DBT.
- To discuss the limitations of DBT.
- To briefly cover supplemental breast imaging modalities.
Main Methods:
- Review of screening and diagnostic applications of DBT.
- Analysis of clinical trial evidence on DBT performance.
- Comparison of DBT with supplemental breast imaging techniques.
Main Results:
- DBT shows reduced recall rates and a slight increase in cancer detection.
- Supplemental modalities like whole-breast ultrasound, MRI, and molecular breast imaging (MBI) demonstrate higher cancer detection rates.
- Contrast-enhanced mammography (CEM) and contrast-enhanced tomography (CET) are under investigation.
Conclusions:
- DBT offers added value in screening and diagnostics.
- Supplemental imaging modalities are crucial for superior sensitivity, particularly in high-risk and dense-breasted patients.
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