Related Experiment Video

Updated: Feb 9, 2026

Generation and Expansion of Primary, Malignant Pleural Mesothelioma Tumor Lines
08:01

Generation and Expansion of Primary, Malignant Pleural Mesothelioma Tumor Lines

Published on: April 21, 2022

2.3K

Is there a role for immunotherapy in malignant pleural mesothelioma?

Alfredo Tartarone1, Rosa Lerose2, Michele Aieta3

  • 1Department of Onco-Hematology, Unit of Medical Oncology, IRCCS-CROB Referral Cancer Center of Basilicata, Rionero in Vulture, PZ, Italy. tarta1@virgilio.it.

Medical Oncology (Northwood, London, England)
|May 31, 2018
PubMed

Insights

Malignant pleural mesothelioma (MPM) is an aggressive cancer with poor prognosis. This review explores promising immunotherapies as potential new treatments for MPM patients.

Area of Science:

  • Oncology
  • Immunology

Background:

  • Malignant pleural mesothelioma (MPM) is a highly aggressive cancer.
  • Asbestos exposure is the primary cause of MPM.
  • Current therapeutic options for MPM are limited, with no standard second-line treatments.

Purpose of the Study:

  • To review the most promising immunotherapies for malignant pleural mesothelioma.
  • To highlight the potential role of immunotherapy in improving MPM outcomes.

Main Methods:

  • Literature review of preclinical and clinical studies on immunotherapy in MPM.
  • Focus on emerging immunotherapeutic strategies and their mechanisms of action.

Main Results:

  • Immunotherapy has shown promise in other cancer types.
  • Several immunotherapeutic agents are under investigation for MPM.
  • Early results suggest potential efficacy, but further research is needed.

Conclusions:

  • Immunotherapy represents a promising avenue for novel MPM treatment strategies.
  • Further clinical investigation is crucial to establish the role of immunotherapy in MPM management.
Keywords:
CAR T cell therapyImmune checkpoint inhibitorsImmunotherapyMalignant pleural mesothelioma

More Related Videos

Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice07:54

Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice

Published on: December 21, 2019

7.3K
Local Anesthetic Thoracoscopy for Undiagnosed Pleural Effusion03:22

Local Anesthetic Thoracoscopy for Undiagnosed Pleural Effusion

Published on: November 10, 2023

1.6K

Related Concept Videos

Pleural Effusion I: Introduction01:25

Pleural Effusion I: Introduction

Pleural effusion is an abnormal fluid accumulation in the pleural cavity, a narrow space between the lungs and the chest wall. It is not a disease per se but rather a symptom or indication of an underlying disease. In normal circumstances, this space contains a small amount of fluid (5 to 15 mL), a lubricant facilitating the non-frictional movement of the pleural surfaces.
There are two main types of pleural effusion: transudative and exudative. They are differentiated using Light's...
4.4K
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
2.0K
Pleural Disorders: Types and Brief Description01:30

Pleural Disorders: Types and Brief Description

The pleura is a vital part of the respiratory system. It's a double-layered membrane surrounding the lungs and lining the chest cavity. The two layers of the pleura are:
711
Pleural Effusion II: Symptoms and Management01:28

Pleural Effusion II: Symptoms and Management

Pleural Effusion Overview
A pleural effusion is the abnormal collection of fluid between the parietal and visceral pleura layers of tissue that form the lining of the lungs and chest cavity. It can occur independently or due to surrounding parenchymal diseases, such as infection, malignancy, or inflammatory conditions.
Clinical Manifestations:
803
Role of Septins01:02

Role of Septins

Septins are the recently discovered fourth major protein component of the cytoskeleton, along with microfilaments, microtubules, and intermediate filaments. These proteins can associate with other cytoskeletal filaments and carry out varied roles or can be free-floating in the cytoplasm.
Cellular Functions of Septins
Recent studies have revealed the multifaceted roles of septins in various cellular processes such as cytokinesis, ciliogenesis, and neurogenesis. Septins act as scaffolds and...
2.2K
The Role of Culture01:23

The Role of Culture

Culture plays a crucial role in shaping self-identity and influencing thought and behavior, a foundational interest within social psychology. The multicultural perspective recognizes that individuals do not exist in a vacuum; instead, their experiences, perceptions, and actions are deeply influenced by the intersecting dimensions of their cultural, ethnic, and social group affiliations.Cultural Influence on Self-Identity and Social PerceptionCultural frameworks inform how individuals define...
436