Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

The Antiviral System of Bacteria and Archaea: CRISPR

The Antiviral System of Bacteria and Archaea: CRISPR

CRISPR stands for Clustered Regularly Interspaced Short Palindromic Repeats is a adaptive immune system found in bacteria and archaea that protects against viral infections. This system enables prokaryotic cells to identify, remember, and neutralize foreign genetic elements, primarily bacteriophages, by storing fragments of the invader’s DNA as a genetic memory.The CRISPR immune response begins during an initial infection. Cas (CRISPR-associated) proteins play a central role in this...

Continuing Care

Continuing Care

Continuing care describes the variety of health, personal, and social services provided over a prolonged period. The need for continuing care is increasing because people are living longer. Many people do not have families or others to care for them. Continuing care is mainly for patients who are disabled, functionally dependent, or suffering from a terminal disease. It is available within institutional settings or in homes. Examples include nursing centers or facilities, assisted living,...

Continuity of a Function

Continuity of a Function

A function is continuous at a point a if three conditions are met: the function is defined at a, the limit of the function as x approaches a exists, and this limit equals the function’s value. Mathematically, this is written asThis definition ensures the graph of the function does not exhibit any breaks, holes, or jumps at that point. Discontinuities occur when any of these conditions fail. A removable discontinuity exists when the two-sided limit exists but the function is either...

Continuity Equation

Continuity Equation

The continuity equation asserts that the mass flow rate must remain constant for a steady flow of an incompressible fluid within a confined system. This principle applies to systems where fluid passes through varying cross-sectional areas, such as nozzles, syringes, and pipes.
The mass flow rate is expressed as:

Continuity Equation

Continuity Equation

The total amount of current flowing per unit cross-sectional area is called the current density. Hence, the current passing through a cross-sectional area can be written as the surface integral of the current density.

Equation of Continuity

Equation of Continuity

Fluid motion is represented by either velocity vectors or streamlines. The volume of a fluid flowing past a given location through an area during a period of time is called the flow rate Q, or more precisely, the volume flow rate. Flow rate and velocity are related—for instance, a river has a greater flow rate if the velocity of the water in it is greater. However, the flow rate also depends on the size and shape of the river. The relationship between flow rate (Q) and average speed (v)...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Design and synthesis of substituted pyrimidines with potent antiviral activity against dengue.

European journal of medicinal chemistry·2026

Same author

Influence of obesity on susceptibility to systemic symptoms and host responses to orthoflaviviral infection: a prospective observational study using yellow fever vaccine to simulate acute infection.

EBioMedicine·2026

Same author

An orthoflavivirus inhibitor targeting multifunctional NS2A protein, a previously unidentified target.

PLoS pathogens·2026

Same author

Neutralizing antibody titers do not predict T cell response to live-attenuated orthoflaviviral vaccination in humans.

Vaccine·2026

Same author

Sulfonyl Anthranilic Acid Analogues Display Pan-Serotype Anti-Dengue Activity by Downregulating the Expression of Ribosomal Proteins Encoded by 5'-Terminal Oligopyrimidine Motif-Containing mRNA.

Journal of medicinal chemistry·2026

Same author

In vitro synthesis of active recombinant orthoflavivirus nonstructural polyproteins in detergent micelles for biochemical analysis.

Npj viruses·2026

Search research articles

Related Experiment Video

Updated: Feb 9, 2026

Assays for the Identification of Novel Antivirals against Bluetongue Virus

Assays for the Identification of Novel Antivirals against Bluetongue Virus

Published on: October 11, 2013

Dengue Antiviral Development: A Continuing Journey.

Jenny G Low^1,2, Rene Gatsinga³, Subhash G Vasudevan³

¹Department of Infectious Diseases, Singapore General Hospital, Singapore, Singapore.

Advances in Experimental Medicine and Biology

|May 31, 2018

Summary

Developing effective dengue antivirals is crucial due to limited treatment options. This review explores innovative drug development approaches, preclinical models, and pathogenesis insights for dengue fever.

Keywords:

Alpha glucosidase inhibitors Dengue biomarker Drug repurposing FDG imaging Host targets

More Related Videos

Visualizing Dengue Virus through Alexa Fluor Labeling

Visualizing Dengue Virus through Alexa Fluor Labeling

Published on: July 9, 2011

Measuring Dengue Virus RNA in the Culture Supernatant of Infected Cells by Real-time Quantitative Polymerase Chain Reaction

Measuring Dengue Virus RNA in the Culture Supernatant of Infected Cells by Real-time Quantitative Polymerase Chain Reaction

Published on: November 1, 2018

Related Experiment Videos

Last Updated: Feb 9, 2026

Assays for the Identification of Novel Antivirals against Bluetongue Virus

Assays for the Identification of Novel Antivirals against Bluetongue Virus

Published on: October 11, 2013

Visualizing Dengue Virus through Alexa Fluor Labeling

Visualizing Dengue Virus through Alexa Fluor Labeling

Published on: July 9, 2011

Measuring Dengue Virus RNA in the Culture Supernatant of Infected Cells by Real-time Quantitative Polymerase Chain Reaction

Measuring Dengue Virus RNA in the Culture Supernatant of Infected Cells by Real-time Quantitative Polymerase Chain Reaction

Published on: November 1, 2018

Area of Science:

Tropical medicine
Virology
Drug discovery

Background:

Dengue fever poses a significant global health threat, particularly in tropical and subtropical regions.
Current therapeutic options for dengue are lacking, and existing vaccines show limited efficacy.
Understanding dengue pathogenesis and improving preclinical models are essential for effective antiviral development.

Purpose of the Study:

To review innovative strategies for dengue therapeutic development.
To discuss outcomes and lessons learned from recent dengue drug discovery efforts.
To highlight the importance of preclinical models and pathogenesis research.

Main Methods:

Review of recent literature on dengue drug development.
Analysis of repurposed drugs and novel chemical entities.
Examination of virus-targeted and host-targeted mechanisms.
Discussion of preclinical testing models and pathogenesis studies.

Main Results:

Several innovative approaches are being explored, including drug repurposing and novel antiviral discovery.
Progress has been made in understanding dengue pathogenesis and developing relevant preclinical models.
Both virus-targeted and host-targeted strategies show promise.

Conclusions:

Continued innovation in drug development, preclinical modeling, and pathogenesis research is vital for combating dengue fever.
A multifaceted approach is necessary to overcome challenges in developing effective dengue therapeutics.
Lessons learned from past efforts can guide future research and development.