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Physical performance across the thyroid function values within the normal range in adult and older persons
Graziano Ceresini1, Michela Marina2, Fulvio Lauretani3
1Department of Medicine and Surgery, Endocrinology of Aging Unit, University Hospital of Parma, Via Gramsci, 14-43126, Parma, Italy. graziano.ceresini@unipr.it.
In older adults, higher free triiodothyronine (FT3) levels within the normal range correlate with better physical performance. Thyroid-stimulating hormone (TSH) and free thyroxine (FT4) showed no significant association with physical function.
Area of Science:
- Endocrinology
- Gerontology
- Physiology
Background:
- Thyroid hormone levels, even within the normal range, may influence health outcomes in euthyroid individuals.
- Understanding these variations is crucial for assessing health in aging populations.
Purpose of the Study:
- To investigate the association between plasma thyroid-stimulating hormone (TSH), free triiodothyronine (FT3), and free thyroxine (FT4) levels and physical performance.
- Focus on middle-aged and older adults with normal thyroid hormone levels.
Main Methods:
- Cross-sectional study of 1060 euthyroid participants (aged 23-102 years) from the Invecchiare in Chianti study.
- Physical performance assessed using the Summary Physical Performance Battery (SPPB) score.
- Plasma TSH, FT3, and FT4 levels served as predictors.
Main Results:
- In older adults, SPPB score was positively associated with FT3 and negatively with TSH and FT4.
- After adjusting for confounders, only FT3 remained significantly associated with SPPB score (P=0.04).
- These associations were consistent when all three hormones were analyzed together.
Conclusions:
- Circulating FT3 levels are positively associated with physical performance in older euthyroid adults.
- FT3 may play a significant role in thyroid-related effects on physical function in this demographic.
- FT4 and TSH levels within the normal range were not significantly associated with physical performance.
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