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Compensatory Limb Use and Behavioral Assessment of Motor Skill Learning Following Sensorimotor Cortex Injury in a Mouse Model of Ischemic Stroke
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Compensatory Limb Use and Behavioral Assessment of Motor Skill Learning Following Sensorimotor Cortex Injury in a Mouse Model of Ischemic Stroke

Published on: July 10, 2014

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Motor function daily living skills 5 years after paediatric arterial ischaemic stroke: a prospective longitudinal

Anna N Cooper1,2, Vicki Anderson1,2,3, Mardee Greenham1,2

  • 1Clinical Sciences, Murdoch Children's Research Institute, Melbourne, Vic., Australia.

Developmental Medicine and Child Neurology
|May 31, 2018
PubMed

Insights

Children with arterial ischemic stroke (AIS) face long-term motor and functional challenges, especially those affected between 30 days and 5 years of age. Early prediction of poor outcomes is crucial for timely intervention.

Area of Science:

  • Pediatric Neurology
  • Neurorehabilitation
  • Developmental Neuroscience

Background:

  • Paediatric arterial ischaemic stroke (AIS) poses significant risks for long-term neurodevelopmental deficits.
  • Understanding the trajectory of motor and functional outcomes is crucial for effective management.

Purpose of the Study:

  • To assess 5-year motor and functional outcomes in children following AIS.
  • To identify factors associated with poorer long-term outcomes in paediatric AIS survivors.

Main Methods:

  • A single-site, cross-sectional study of 33 children (21 males, 12 females) with AIS, stratified by age at diagnosis (neonates, preschool, school age).
  • Motor and functional outcomes were assessed at 5 years post-stroke.
  • Neurological outcomes were evaluated using the Pediatric Stroke Outcome Measure (PSOM) at 1 month and >4 years post-stroke.

Main Results:

  • Children demonstrated significantly poorer motor function, quality of life, and adaptive behaviours 5 years after AIS compared to age expectations.
  • The preschool age group (30 days–5 years) exhibited the highest rates of fine and gross motor impairment.
  • Poorer fine motor skills were linked to subcortical-only lesions and larger lesion sizes; poorer gross motor outcomes correlated with preschool age, bilateral lesions, and early PSOM impairment.

Conclusions:

  • Children with AIS are at high risk for persistent motor and functional impairments.
  • The preschool age group is particularly vulnerable, highlighting the need for targeted interventions.
  • Early identification of predictors for poor outcomes is essential for optimizing long-term rehabilitation strategies.
Abstract

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