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Updated: Feb 9, 2026

Experimental Human Pneumococcal Carriage
Published on: February 15, 2013
Antiphospholipid Syndrome Complicating Pneumococcal Meningitis
Suresh Mekala1, C G Delhi Kumar2, Reena Gulati1
1Department of Pediatrics, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India.
Insights
Antiphospholipid syndrome (APS) can occur in children with meningitis, even without a lupus diagnosis. This case highlights APS as a potential cause of thrombosis in pediatric meningitis patients.
Area of Science:
- Pediatric Autoimmunology
- Pediatric Thrombosis
- Neurology
Background:
- Antiphospholipid syndrome (APS) is an autoimmune disorder causing thrombosis.
- It affects multiple body systems, including arteries and veins.
- Pediatric cases are less common but significant.
Background:
Antiphospholipid syndrome is a multisystem auto-immune disorder characterized by arterial or venous thrombosis in children.
Case Characteristics:
11-year-old child with pneumococcal meningitis also had cerebral sinus vein thrombosis and pulmonary artery segmental thrombosis.
Observation:
Pro-thrombotic evaluation showed positive lupus anticoagulant at baseline and after 12 weeks. Investigations for lupus were negative at admission and after one year of follow-up.
Message:
Antiphospholipid syndrome is a possibility even in thrombosis occurring in the setting of meningitis.
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