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Flucloxacillin: A Review of Characteristics, Properties and Analytical Methods

Mariana Nunes de Menezes1, Bianca Aparecida de Marco2, Flávia Angélica Masquio Fiorentino2

  • 1a Laboratory of Applied Pharmacology, School of Health Sciences , Pontifícia Universidade Católica do Rio Grande do Sul - PUCRS , Porto Alegre , Brazil.

Critical Reviews in Analytical Chemistry
|May 31, 2018
PubMed

Insights

Flucloxacillin (FLU) is a vital antibiotic, but its quality control requires effective analytical methods. This study reviews FLU characteristics and determination techniques, emphasizing the need for sustainable analytical approaches.

Area of Science:

  • Pharmaceutical analysis
  • Antimicrobial resistance
  • Analytical chemistry

Background:

  • Bacterial resistance is a significant global health concern, impacting drug development and quality control.
  • Flucloxacillin (FLU) is a bactericidal antibiotic, with FLU sodium used in pharmaceutical formulations, effective against penicillinase.
  • Accurate qualitative and quantitative analyses are crucial for pharmaceutical quality control and public health.

Purpose of the Study:

  • To highlight the characteristics of flucloxacillin (FLU) as a key antibiotic.
  • To review methods for determining FLU in pharmaceutical products and biological matrices.
  • To emphasize the need for developing sustainable and ecologically sound analytical methods for FLU analysis.

Main Methods:

  • Literature review of analytical methods for flucloxacillin determination.
  • Discussion of high-performance liquid chromatography (HPLC) as a common method.
  • Identification of limitations of current methods, including toxic solvent use and waste generation.

Main Results:

  • High-performance liquid chromatography (HPLC) is a prominent method for FLU determination.
  • Existing HPLC methods often involve toxic solvents, long run times, and significant waste.
  • There is a growing imperative to develop greener, more sustainable analytical techniques.

Conclusions:

  • Effective quality control of flucloxacillin is essential in combating microbial resistance.
  • Current analytical methods for FLU, particularly HPLC, have environmental drawbacks.
  • Future research should focus on developing sustainable and eco-friendly analytical methods for FLU determination.
Keywords:
Analytical methodsflucloxacillinquality controlsustainable method

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