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Three-Dimensional Pathology Specimen Modeling Using "Structure-From-Motion" Photogrammetry: A Powerful New Tool for
John Turchini, Michael E Buckland, Anthony J Gill
1From the Cancer Diagnosis and Pathology Group, Kolling Institute of Medical Research, Royal North Shore Hospital, Sydney, Australia (Drs Turchini, Gill, and Battye); the Northern Clinical School, University of Sydney, Sydney, Australia (Drs Turchini, Buckland, and Gill); the Department of Anatomical Pathology, Royal North Shore Hospital, St Leonards, Australia (Drs Turchini and Gill); the Department of Neuropathology, Royal Prince Alfred Hospital, and the Brain and Mind Centre, University of Sydney, Camperdown, Australia (Dr Buckland); and the Department of Anatomical Pathology, Dorevitch Pathology, Heidelberg, Australia (Dr Battye).
Three-dimensional (3D) photogrammetry enables detailed digital modeling of surgical pathology specimens. This technology enhances medical education and clinicopathologic correlation for surgeons, revolutionizing pathology practice.
Area of Science:
- Anatomic Pathology
- Digital Imaging
- Medical Technology
Background:
- Three-dimensional (3D) photogrammetry is an image-based modeling technique.
- It is widely used in geomorphology and artificial imagery.
- Its application in anatomic pathology is novel.
Purpose of the Study:
- To describe a 3D photogrammetry system for creating high-quality 3D digital models.
- To outline its uses in routine surgical pathology and medical education.
Main Methods:
- Specimens from two laboratories were modeled.
- Automated capture and photogrammetry process using user control software, a DSLR camera, and a digital turntable.
- 3D models were generated and outputted as PDF files.
Main Results:
- Identified entities in specimens were well demarcated and easily distinguished from adjacent normal tissue.
- Color preservation was achieved.
- Discernible concave and convex structures, including surgically important regions, were identifiable.
Conclusions:
- Macroscopic 3D modeling of specimens is achievable with Structure-From-Motion photogrammetry.
- This technology can be rapidly and easily integrated into routine laboratory practice.
- Benefits include improved clinicopathologic correlation, enhanced medical education, and potential for virtual reality and 3D-printing applications.
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