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Expression profile of long noncoding RNAs in children with systemic lupus erythematosus: a microarray analysis
Shipeng Li1, Caifeng Li2, Junmei Zhang1
1Department of Rheumatology and Immunology, Beijing Children's Hospital, Capital Medical University, National Centre for Children's Health, Beijing, China.
Clinical and Experimental Rheumatology
|May 31, 2018
Summary
This study reveals distinct long noncoding RNA (lncRNA) expression patterns in children with systemic lupus erythematosus (SLE). These findings offer new insights into SLE pathogenesis and potential diagnostic biomarkers.
Area of Science:
- Genetics
- Molecular Biology
- Immunology
Background:
- Long noncoding RNAs (lncRNAs) are increasingly recognized for their roles in biological processes.
- Understanding lncRNA involvement in pediatric systemic lupus erythematosus (cSLE) is limited.
Purpose of the Study:
- To investigate lncRNA expression profiles in cSLE.
- To explore the functional roles of lncRNAs in cSLE pathogenesis.
Main Methods:
- Differential expression analysis using lncRNA and mRNA microarrays.
- Validation of expression changes via quantitative polymerase chain reaction (qPCR).
- Functional enrichment analysis using Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways.
Main Results:
- Identified 1042 differentially expressed lncRNAs and 1162 differentially expressed mRNAs between cSLE patients and healthy controls.
- Constructed a lncRNA-mRNA co-expression network with 817 matched pairs.
- lncRNAs were found to be involved in pathways critical to SLE pathobiology.
Conclusions:
- First characterization of lncRNA and mRNA expression profiles in cSLE.
- Proposed potential roles for lncRNAs in SLE pathogenesis.
- Results suggest lncRNAs as potential diagnostic biomarkers for SLE.
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