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Updated: Feb 9, 2026

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Published on: January 6, 2023
Exosomes in acute myeloid leukemia inhibit hematopoiesis
Michael Boyiadzis1, Theresa L Whiteside2
1Division of Hematology-Oncology, Departments of Medicine.
Purpose Of Review:
Exosomes are cell-derived, biologically active membrane-bound vesicles, and are emerging as key modulators of hematopoiesis. Recent studies have provided a clearer understanding of the mechanisms whereby blast-derived exosomes act to suppress hematopoiesis in acute myeloid leukemia (AML).
Recent Findings:
Exosomes released from leukemia blasts have been shown to suppress hematopoietic progenitor cell (HPC) functions indirectly through stromal reprogramming of niche-retention factors and also as a consequence of AML exosome-directed microRNA delivery to HPC. Furthermore, exosomes secreted by AML blasts remodel the bone marrow niche into a leukemia growth-permissive microenvironment.
Summary:
Exosomes suppress hematopoiesis in AML. Strategies to block the production, secretion and reprogramming that exosomes induce may be a novel therapeutic approach in AML and other leukemias.
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