Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Diagnosis of hyperparathyroidism.

P J Davis, F B Davis

    Otolaryngology--Head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
    |February 1, 1985
    PubMed
    Summary

    Intact parathyroid hormone (PTH) immunoassays effectively distinguish primary hyperparathyroidism from cancer-related hypercalcemia. These assays identify PTH-like substances, aiding in diagnosing hypercalcemic states.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Two-Year Outcomes of Postoperative Spine Infection: Implant Retention and Predictors of Treatment Failure.

    Open forum infectious diseases·2026
    Same author

    Canadian Surgery Forum.

    Canadian journal of surgery. Journal canadien de chirurgie·2022
    Same author

    Abstracts of presentations to the Annual Meetings of the Canadian Association of General Surgeons Canadian Association of Thoracic Surgeons Canadian Hepato-Pancreato-Biliary Society Canadian Society of Surgical Oncology Canadian Society of Colon and Rectal Surgeons: Victoria, BC Sept. 10-13, 2009.

    Canadian journal of surgery. Journal canadien de chirurgie·2022
    Same author

    The thyroid hormone-αvβ3 integrin axis in ovarian cancer: regulation of gene transcription and MAPK-dependent proliferation.

    Oncogene·2015
    Same author

    Heated humidified high-flow nasal cannula therapy in children.

    Archives of disease in childhood·2014
    Same author

    Acute hemodynamic changes after rapid intravenous bolus dosing of dexmedetomidine in pediatric heart transplant patients undergoing routine cardiac catheterization.

    Anesthesia and analgesia·2010

    Area of Science:

    • Endocrinology
    • Oncology
    • Biochemistry

    Background:

    • Hypercalcemia is a common complication of malignancy and primary hyperparathyroidism.
    • Distinguishing between these conditions is crucial for appropriate patient management.
    • Circulating parathyroid hormone (PTH)-like substances produced by tumors can mimic primary hyperparathyroidism.

    Purpose of the Study:

    • To evaluate the efficacy of immunoassays in differentiating primary hyperparathyroidism from tumoral hypercalcemic states.
    • To assess the diagnostic utility of intact, N-terminal PTH assays.

    Main Methods:

    • Utilized immunoassays targeting specific regions of the parathyroid hormone (PTH) molecule.
    • Analyzed serum PTH levels, including intact and N-terminal assays.
    • Compared diagnostic performance with serum chloride:phosphate ratio and nephrogenous cyclic AMP measurements.

    Main Results:

    • Intact, N-terminal PTH assays demonstrate the highest discriminant function for distinguishing hypercalcemic states.
    • Tumoral hypercalcemia associated with prostaglandin or osteoclast-activating factor typically shows suppressed serum PTH levels.
    • PTH-like substances are detected by immunoassays but often appear as normal or low values in intact, N-terminal systems.

    Conclusions:

    • Intact, N-terminal PTH immunoassays are valuable tools for differentiating primary hyperparathyroidism from tumoral hypercalcemia.
    • Serum chloride:phosphate ratio and nephrogenous cyclic AMP lack sufficient discriminatory power.
    • Future advancements may include quantitative bone biopsy histomorphometry and in vitro bioassays for enhanced diagnostic accuracy.

    Related Experiment Videos