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The role of SGLT2 inhibitors in managing type 2 diabetes
Velen Tat1, Christopher P Forest
1Velen Tat is a PA fellow in the ED of Arrowhead Regional Medical Center in Colton, Calif. The author began this article while a student in the Primary Care PA Program at the University of Southern California's Keck School of Medicine in Alhambra, Calif. Christopher P. Forest is a professor of health science and human services at California State University Monterey Bay and founding program director of the Master of Science PA program. The authors have disclosed no potential conflicts of interest, financial or otherwise.
Abstract:
The sodium glucose cotransporter 2 (SGLT2) inhibitors canagliflozin, dapagliflozin, empagliflozin, and ertugliflozin represent a novel class of medications to manage type 2 diabetes through urinary excretion of glucose. These drugs block glucose reabsorption by the kidneys to increase glucosuria. These drugs provide hemoglobin A1C reduction, promote weight loss, and remain hypoglycemic-neutral when not used in combination with insulin or secretagogues. Canagliflozin and empagliflozin have shown cardiovascular benefit. The potential to reduce the risk of cardiovascular death in patients with type 2 diabetes, along with the benefit of weight reduction, makes these new agents useful tools for the primary care provider.
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