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Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication

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Ethyl Glucuronide in Alcoholic Beverages.

Alexander Müller¹, Stefanie Iwersen-Bergmann¹

¹Department of Legal Medicine, University Medical Center Hamburg-Eppendorf, Toxicology, Hamburg, Germany.

Alcohol and Alcoholism (Oxford, Oxfordshire)

|May 31, 2018

Summary

This summary is machine-generated.

Ethyl glucuronide (EtG) is naturally present in wine but not in beer or spirits. This finding is crucial for interpreting EtG biomarker testing, particularly hair analysis, to avoid misinterpretation due to external contamination.

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Area of Science:

Forensic Toxicology
Analytical Chemistry
Biomarker Analysis

Background:

Ethyl glucuronide (EtG) is a biomarker used to assess alcohol consumption.
The presence of EtG in alcoholic beverages themselves can influence biomarker test results.
Understanding the natural occurrence of EtG in beverages is critical for accurate interpretation of abstinence.

Purpose of the Study:

To investigate the presence and concentration of ethyl glucuronide (EtG) in a variety of alcoholic beverages.
To determine if EtG is a natural component of different types of alcoholic drinks.
To assess the implications of beverage-derived EtG on biomarker testing.

Main Methods:

Analysis of 114 alcoholic beverages, including wine, beer, spirits, and liqueurs.
Utilized a validated liquid chromatography/tandem mass spectrometry (LC/MS-MS) assay for precise quantification.
Samples were sourced from diverse manufacturers and geographical origins to ensure representativeness.

Main Results:

Ethyl glucuronide (EtG) was detected in all analyzed wine samples (n=42), with concentrations varying by type (red, white, sparkling).
EtG was consistently absent in all tested distilled spirits (n=52) and beer samples (n=20), irrespective of origin or type.
Highest EtG levels were observed in red wine, ranging from 1425 to 3720 μg/l.

Conclusions:

Wine serves as a significant external source of ethyl glucuronide (EtG).
The presence of EtG in wine, potentially in milligram quantities per bottle, must be considered in biomarker testing.
External contamination from wine consumption can impact the interpretation of EtG hair analysis, necessitating careful consideration in forensic and clinical settings.