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Related Experiment Video

Updated: Feb 9, 2026

Gait Analysis of Age-dependent Motor Impairments in Mice with Neurodegeneration
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Brain Structure Covariance Associated With Gait Control in Aging.

Gilles Allali1,2, Maxime Montembeault3,4, Simona M Brambati3

  • 1Department of Neurology, Geneva University Hospital, University of Geneva, Switzerland.

The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
|May 31, 2018
PubMed
Summary

Brain networks for gait control change with walking speed in older adults. Challenging walking conditions recruit emotional control regions, highlighting the complexity of aging gait.

Keywords:
AgingAnatomical structural covarianceGaitMotor controlNeuroimaging

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Area of Science:

  • Neuroscience
  • Gerontology
  • Brain Imaging

Background:

  • Age-related changes affect brain structures crucial for gait control.
  • Structural and functional brain imaging reveal these age-related alterations.
  • Understanding these changes is vital for maintaining mobility in older adults.

Purpose of the Study:

  • To investigate gray matter networks linked to gait control in aging.
  • Utilize structural covariance analysis to map these brain networks.
  • Examine how different walking conditions influence gait-related brain networks.

Main Methods:

  • Cross-sectional study of 326 nondemented older adults (mean age 71.3 years).
  • Assessed walking speed under normal, fast, and dual-task (backward counting) conditions.
  • Employed structural covariance analysis to identify gray matter network correlations.

Main Results:

  • Slower walking speed correlated with reduced gray matter volume in the right thalamus (normal walking), right caudate nucleus (fast walking), and left middle frontal gyrus (dual-task walking).
  • Prefrontal regions formed networks common to all walking conditions.
  • Specific networks emerged for rapid walking (right caudate with hippocampus, amygdala, insula) and dual-task walking (left middle frontal gyrus with cuneus).

Conclusions:

  • Brain networks supporting gait control are dynamic and condition-dependent in aging.
  • Challenging walking tasks recruit distributed networks, including those involved in emotional regulation.
  • Gait control in older adults relies on a complex interplay of cognitive and emotional brain regions.