Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Buffer Effectiveness02:19

Buffer Effectiveness

55.5K
Buffer solutions do not have an unlimited capacity to keep the pH relatively constant . Instead, the ability of a buffer solution to resist changes in pH relies on the presence of appreciable amounts of its conjugate weak acid-base pair. When enough strong acid or base is added to substantially lower the concentration of either member of the buffer pair, the buffering action within the solution is compromised.
The buffer capacity is the amount of acid or base that can be added to a given volume...
55.5K
Framing Effects03:26

Framing Effects

8.0K
Information is everywhere and its presentation—such as how and when items are presented—can impact our perceptions and decisions surrounding the info. This broad concept umbrellas framing effects—influences that occur due to the way information is framed in its appearance, whether it’s purely the order or the specific wording of a message. Let’s take a look at numerous ways in which two versions of something can objectively say the same thing, yet we respond in...
8.0K
Biological Effects of Radiation02:59

Biological Effects of Radiation

18.0K
All radioactive nuclides emit high-energy particles or electromagnetic waves. When this radiation encounters living cells, it can cause heating, break chemical bonds, or ionize molecules. The most serious biological damage results when these radioactive emissions fragment or ionize molecules. For example, α and β particles emitted from nuclear decay reactions possess much higher energies than ordinary chemical bond energies. When these particles strike and penetrate matter, they...
18.0K
Physiology of Enteric Nervous System and Gut Health01:05

Physiology of Enteric Nervous System and Gut Health

1.0K
The gastrointestinal tract, responsible for the digestion and absorption of nutrients, is safeguarded by the intestinal barrier, which consists of secretory, physical, and immune components. At the forefront is the secretory barrier, composed of essential elements such as mucus, gut microbiota, and defense proteins. They collaborate to break down food particles, facilitate nutrient absorption, and maintain optimal gut health. These secretory components ensure the smooth functioning of the...
1.0K
Glucose Homeostasis: Pancreatic Islets and Insulin Secretion01:27

Glucose Homeostasis: Pancreatic Islets and Insulin Secretion

2.6K
The pancreatic islets comprising only 1%-2% of the volume are highly vascularized and innervated mini-organs. They contain five endocrine cell types, including β cells that secrete insulin, which is synthesized as a single polypeptide chain, preproinsulin, processed to proinsulin, and finally to insulin and C-peptide. This process is complex and regulated, involving the Golgi complex, the endoplasmic reticulum, and the secretory granules of the β cell.
Insulin and C-peptide are...
2.6K
Self-Awareness and Its Effects01:21

Self-Awareness and Its Effects

318
Self-awareness is a psychological state in which the individual becomes the focal point of their attention. This inward focus transforms the self into an object of contemplation and assessment, influencing how individuals perceive their actions and their alignment with personal and societal standards.Triggers and Contexts for Self-AwarenessSelf-awareness can be activated by external stimuli that make individuals visually or audibly aware of themselves, such as mirrors, cameras, or recordings.
318

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Maternal trans-vaccenic acid shapes neonatal T cell development and early-life immune imprinting.

Science (New York, N.Y.)·2026
Same author

Telemedicine-Based Diabetes Management for Incarcerated Individuals.

JAMA network open·2026
Same author

Adipocyte-specific FFA2 deletion leads to increased adipose inflammation and is associated with altered intestinal lipid handling in mice.

Physiological reports·2026
Same author

Hyperglycemia During Acute Pancreatitis and Progression to Early-Onset Diabetes After Recovery: Preliminary Findings From the Diabetes Related to Acute Pancreatitis and Its Mechanisms (DREAM) Study.

Diabetes care·2026
Same author

Toxic metals impact gut microbiota and metabolic risk in five African-origin populations.

Gut microbes reports·2026
Same author

Associations between dietary patterns and diabetes in patients with acute pancreatitis: a cross-sectional analysis from the DREAM study.

Nutrition journal·2026

Related Experiment Video

Updated: Feb 9, 2026

A Method to Assess Bacteriocin Effects on the Gut Microbiota of Mice
07:54

A Method to Assess Bacteriocin Effects on the Gut Microbiota of Mice

Published on: July 25, 2017

14.8K

Gut Microbiota: FFAR Reaching Effects on Islets.

Medha Priyadarshini1, Guadalupe Navarro1, Brian T Layden1,2

  • 1Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Illinois at Chicago, Chicago, Illinois.

Endocrinology
|May 31, 2018
PubMed
Summary

Free fatty acid receptors 2 and 3 (FFA2 and FFA3) regulate pancreatic beta cells, impacting insulin secretion, survival, and proliferation. These receptors offer potential therapeutic targets for type 1 and type 2 diabetes.

More Related Videos

Investigating the Alleviating Effects of Bacillus cereus Administration on Colitis through Gut Microbiota Modulation
08:34

Investigating the Alleviating Effects of Bacillus cereus Administration on Colitis through Gut Microbiota Modulation

Published on: July 27, 2022

1.3K
Applying Advanced In Vitro Culturing Technology to Study the Human Gut Microbiota
06:23

Applying Advanced In Vitro Culturing Technology to Study the Human Gut Microbiota

Published on: February 15, 2019

14.9K

Related Experiment Videos

Last Updated: Feb 9, 2026

A Method to Assess Bacteriocin Effects on the Gut Microbiota of Mice
07:54

A Method to Assess Bacteriocin Effects on the Gut Microbiota of Mice

Published on: July 25, 2017

14.8K
Investigating the Alleviating Effects of Bacillus cereus Administration on Colitis through Gut Microbiota Modulation
08:34

Investigating the Alleviating Effects of Bacillus cereus Administration on Colitis through Gut Microbiota Modulation

Published on: July 27, 2022

1.3K
Applying Advanced In Vitro Culturing Technology to Study the Human Gut Microbiota
06:23

Applying Advanced In Vitro Culturing Technology to Study the Human Gut Microbiota

Published on: February 15, 2019

14.9K

Area of Science:

  • Endocrinology
  • Immunology
  • Microbiology

Background:

  • G protein-coupled receptors, free fatty acid receptors 2 and 3 (FFA2 and FFA3), sense short-chain fatty acids (SCFAs).
  • These receptors are involved in immune and metabolic regulation, including hormone secretion.
  • Recent findings highlight their role in pancreatic beta cells, affecting insulin secretion, survival, and proliferation.

Purpose of the Study:

  • To review the known roles of FFA2 and FFA3 in pancreatic beta cells.
  • To discuss the potential of these receptors as therapeutic targets for diabetes.
  • To explore the link between gut microbiota and beta cells via SCFA signaling.

Main Methods:

  • Literature review of studies on FFA2, FFA3, SCFAs, and pancreatic beta cells.
  • Analysis of receptor expression and function in immune and beta cells.
  • Discussion of clinical implications and therapeutic potential.

Main Results:

  • FFA2 and FFA3 significantly influence insulin secretion, beta-cell survival, and proliferation.
  • These receptors are expressed on both immune and beta cells, suggesting roles in both type 1 and type 2 diabetes.
  • SCFA signaling through FFA2 and FFA3 provides a novel connection between gut microbiota and pancreatic beta cells.

Conclusions:

  • FFA2 and FFA3 are critical regulators of beta-cell function and survival.
  • Targeting FFA2 and FFA3 presents a promising therapeutic strategy for diabetes.
  • The gut microbiota-beta cell axis mediated by SCFAs warrants further investigation for clinical translation.