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Aging- and vascular-related pathologies.

Shu Wen Wen1, Connie H Y Wong1

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As the global population ages, age-related diseases like atherosclerosis, stroke, and Alzheimer's disease are increasing. Biological aging impairs vascular function, significantly raising the risk for these conditions.

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Area of Science:

  • Gerontology
  • Vascular Biology
  • Neuroscience

Background:

  • The global population aged over 65 will double by 2050, leading to more age-related diseases.
  • Cardiovascular, cerebrovascular, and neurodegenerative diseases are common in the elderly.
  • Vascular dysfunction is a common link among these prevalent age-related pathologies.

Purpose of the Study:

  • To review clinical and experimental evidence on how biological aging impacts vascular function.
  • To explore the contribution of aging to atherosclerosis, stroke, and Alzheimer's disease.

Main Methods:

  • Review of current clinical evidence.
  • Review of experimental findings.

Main Results:

  • Aging induces structural and functional impairments in vascular networks.
  • Impaired vascular function, alongside cell senescence and inflammation, increases susceptibility to age-related diseases.

Conclusions:

  • Biological aging is a significant contributor to vascular dysfunction.
  • Understanding aging's impact on vasculature is crucial for addressing atherosclerosis, stroke, and Alzheimer's disease.