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Psychoneuroimmunology: Cardiovascular Disease

Psychoneuroimmunology: Cardiovascular Disease

Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
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Overview of the Cardiovascular System

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The cardiovascular system is a vital transportation system in the body. It comprises the heart and blood vessels and facilitates the exchange of gases, nutrients, and waste products.
Heart
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The regulation of the cardiovascular system allows the body to adapt to various demands and maintain homeostasis.
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Inspection is the initial step in assessing the cardiovascular system. It involves a detailed visual examination that provides crucial information about a patient's circulatory and cardiac health. This systematic process, conducted from head to toe, helps identify signs of cardiovascular conditions by observing physical appearance, skin and mucous membranes, jugular and carotid pulsations, chest symmetry, and the condition of the extremities.
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Updated: Feb 9, 2026

In Silico Clinical Trials for Cardiovascular Disease

In Silico Clinical Trials for Cardiovascular Disease

Published on: May 27, 2022

Nutriepigenetics and cardiovascular disease.

Anastasia Z Kalea^1,2,3, Konstantinos Drosatos⁴, Jessica L Buxton^5,6

¹Institute of Liver and Digestive Health, Division of Medicine.

Current Opinion in Clinical Nutrition and Metabolic Care

|May 31, 2018

Summary

This summary is machine-generated.

Dietary factors can modify epigenetic alterations linked to cardiovascular disease (CVD). Research explores how nutrients and dietary patterns influence the epigenome for CVD prevention and therapy.

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Area of Science:

Nutritional epigenetics
Cardiovascular disease research

Background:

Epigenetic alterations are increasingly recognized as contributors to cardiovascular disease (CVD).
Dietary components and patterns can influence epigenetic mechanisms, impacting CVD risk factors like obesity, inflammation, and oxidative stress.

Purpose of the Study:

To review the current understanding of epigenetic alterations in CVD.
To explore the potential of dietary factors as epigenetic modifiers for CVD prevention and treatment.

Main Methods:

Review of epigenome-wide association studies (EWAS).
Analysis of candidate gene approaches.
Inclusion of functional studies in cell culture and animal models.

Main Results:

Nutrients and dietary patterns impact DNA methylation, histone acetylation, and telomere length.
Dietary imbalances (e.g., high-fat diets, nutrient deficiencies) and bioactive compounds (e.g., polyphenols) affect epigenetic enzymes and CVD-related pathways.
Cardioprotective diets like the Mediterranean diet are associated with altered gene methylation and expression relevant to inflammation.

Conclusions:

Dietary interventions show promise for modifying the cardiovascular epigenome.
Further research is needed to elucidate mechanisms and identify reversible nutriepigenetic effects for effective CVD prevention and therapy.