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Related Experiment Video

Updated: Feb 9, 2026

Author Spotlight: Studying Behavior of Acanthamoeba to Develop Targeted Strategies for Preventing Acanthamoeba Keratitis

Author Spotlight: Studying Behavior of Acanthamoeba to Develop Targeted Strategies for Preventing Acanthamoeba Keratitis

Published on: September 20, 2024

Acanthamoeba Keratitis: Are Recent Cases More Severe?

Mehdi Roozbahani¹, Kristin M Hammersmith¹, Christopher J Rapuano¹

¹Ophthalmology Department, Cornea Service, Wills Eye Hospital, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA.

|May 31, 2018

Summary

Recent Acanthamoeba keratitis (AK) patients at Wills Eye Hospital are older, present later with worse vision, and have poorer treatment outcomes compared to earlier cases. This indicates a significant shift in AK presentation and prognosis.

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Last Updated: Feb 9, 2026

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Area of Science:

Ophthalmology
Infectious Diseases
Corneal Diseases

Background:

Acanthamoeba keratitis (AK) is a severe microbial keratitis.
Understanding trends in AK presentation and outcomes is crucial for effective management.

Purpose of the Study:

To identify recent changes in disease severity and visual outcomes for Acanthamoeba keratitis (AK) patients.
To compare patient characteristics and treatment outcomes between two time intervals (2009-2012 and 2013-2015).

Main Methods:

Retrospective chart review of AK cases diagnosed at Wills Eye Hospital (WEH) from 2009 to 2015.
Defined treatment failure as best-corrected visual acuity worse than 20/100 and/or requiring keratoplasty.
Compared patient demographics, clinical presentation, and treatment outcomes between two distinct time periods.

Main Results:

Treatment failure rates increased significantly in the later interval (68% vs. 28%).
Patients in the later interval were older, received more pre-diagnosis corticosteroids, and presented with delayed treatment initiation and poorer vision.
A significant shift in patient profile and disease severity was observed.

Conclusions:

The demographic profile and clinical presentation of AK patients at WEH have changed significantly in recent years.
Current AK patients are older, present with more severe keratitis, later symptom onset, and worse initial vision.
Treatment outcomes for Acanthamoeba keratitis have worsened in the recent patient cohort.