Differentiated Regional Homogeneity in Progressive Mild Cognitive Impairment: A Study With Post Hoc Label

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A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment
12:18

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment

Published on: January 11, 2020

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Suping Cai1, Yubo Wang1, Yafei Kang1

  • 11 School of Life Science and Technology, Xidian University, Xi'an, Shaanxi, China.

American Journal of Alzheimer'S Disease and Other Dementias
|June 1, 2018
PubMed
Abstract

Insights

Brain activity patterns in mild cognitive impairment (MCI) subtypes differ. Regional homogeneity (ReHo) changes in specific brain regions may predict cognitive trajectories in MCI patients.

Area of Science:

  • Neuroscience
  • Geriatric Medicine
  • Cognitive Neurology

Background:

  • Mild cognitive impairment (MCI) represents a transitional stage between normal cognition and Alzheimer's disease (AD).
  • Longitudinal studies reveal that MCI patients can revert to normal cognition (MCI_R), remain stable (MCI_S), or progress to AD (MCI_P).
  • Understanding the distinct neural underpinnings of these MCI subtypes is crucial for targeted interventions.

Purpose of the Study:

  • To investigate the local brain activity differences among MCI subtypes with varying clinical outcomes.
  • To utilize the regional homogeneity (ReHo) measure to characterize brain activity in MCI_R, MCI_S, and MCI_P groups.

Main Methods:

  • Employed the regional homogeneity (ReHo) technique to assess local brain activity.
  • Compared ReHo patterns in three MCI subgroups (MCI_R, MCI_S, MCI_P) against age-matched healthy controls.

Main Results:

  • MCI_R group: Increased ReHo in the left insula, decreased ReHo in the left superior temporal gyrus.
  • MCI_S group: Increased ReHo in the left inferior frontal gyrus orbitalis (IFG_orb), decreased ReHo in the left inferior parietal lobe.
  • MCI_P group: Increased ReHo in the left IFG_orb, decreased ReHo in the left putamen.

Conclusions:

  • Distinct ReHo alterations observed in each MCI subgroup suggest unique neural signatures.
  • These findings provide potential evidence for developing differentially active interventions tailored to specific MCI patient trajectories.
  • Characterizing ReHo changes may aid in predicting cognitive decline or recovery in individuals with MCI.
Keywords:
Alzheimer’s diseasemild cognitive impairmentregional homogeneityresting-state functional magnetic resonance imaging

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