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Updated: Feb 9, 2026

Use of Interferon-γ Enzyme-linked Immunospot Assay to Characterize Novel T-cell Epitopes of Human Papillomavirus
Published on: March 8, 2012
Ocular Human Papillomavirus Infections
Mehenaz Hanbazazh, Kymberly A Gyure1
1From the Department of Pathology, West Virginia University School of Medicine, Morgantown.
Context:
- Human papillomavirus (HPV) has a well-known role in the pathogenesis of squamous cell carcinoma and precursor lesions of the cervix, anogenital region, and head and neck, but its role in the development of squamous neoplasms of the eye, particularly the conjunctiva, remains unclear.
Objective:
- To review recent evidence implicating HPV in the pathophysiology of ocular lesions.
Data Sources:
- Published articles obtained from a PubMed search of the English literature were the primary sources for this review.
Conclusions:
- The low-risk HPV types 6 and 11 appear to play a role in the development of at least a subset of conjunctival squamous papillomas. The role of HPV in the pathogenesis of pterygium and ocular surface squamous neoplasia is less well defined. There is evidence to suggest that HPV may be a cofactor in the development of these lesions, acting in concert with ultraviolet radiation and/or human immunodeficiency virus infection in a subgroup of cases.
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