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Updated: Feb 9, 2026

Use of Interferon-γ Enzyme-linked Immunospot Assay to Characterize Novel T-cell Epitopes of Human Papillomavirus
Published on: March 8, 2012
Human Papillomavirus Infection of the Skin
1From the Department of Pathology, West Virginia University School of Medicine, Morgantown.
Context:
- Human papillomavirus is implicated in the pathogenesis of benign and malignant neoplasms of the skin.
Objective:
- To review the role of human papillomavirus in the development of malignancies and their precursor lesions in skin.
Data Sources:
- The study comprised a review of the literature.
Conclusions:
- The use of low-grade squamous intraepithelial lesion and high-grade squamous intraepithelial lesion terminology brings order and simplicity to these lesions, correlates with the current understanding of the biology of human papillomavirus infections, and helps to promote accurate diagnosis of and appropriate treatment for these lesions.
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