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Updated: Feb 9, 2026

Evaluating Leaf Responses to Microbial Secondary Metabolites Using A High-Throughput Format
Published on: December 5, 2025
Secondary metabolites produced by Sardiniella urbana, a new emerging pathogen on European hackberry
Alessio Cimmino1, Lucia Maddau2, Marco Masi1
1a Dipartmento di Scienze Chimiche , Università di Napoli Federico II, Complesso Universitario Monte S. Angelo , Napoli , Italy.
Abstract:
In this study the production of secondary metabolites by a virulent strain of Sardiniella urbana, a recently described pathogen originally found on declining European hackberry trees in Italy, was investigated for the first time. Chemical analysis of the culture filtrate extracts led to the isolation of three well known compounds as R-(-)-mellein and (3R,4R)-and (3R,4S)-4-hydroxy melleins which were identified by spectroscopic methods (essentially NMR and ESIMS). The isolated compounds were tested for their phytotoxic, antifungal and zootoxic activities. Among them, only R-(-)-mellein was found to be active.
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