Related Experiment Video
Updated: Feb 9, 2026
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Co-culture of Glutamatergic Neurons and Pediatric High-Grade Glioma Cells Into Microfluidic Devices to Assess Electrical Interactions
Published on: November 17, 2021
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Malignant Intracranial High Grade Glioma and Current Treatment Strategy
Xiang Zhang1, Wei Zhang1, Xing-Gang Mao1
1Department of Neurosurgery, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.
Current Cancer Drug Targets
|June 1, 2018
Summary
Malignant high-grade glioma (HGG) requires new treatments due to recurrence and the blood-brain barrier. Local drug delivery and targeted therapies show promise for inhibiting HGG invasion, proliferation, and recurrence.
Area of Science:
- Neuro-oncology
- Oncology
- Pharmacology
Background:
- Malignant high-grade glioma (HGG) is a common and fatal primary intracranial tumor.
- HGG frequently recurs near the resection site, and the blood-brain barrier hinders systemic chemotherapy.
- There is a critical need for novel therapeutic strategies for HGG.
Purpose of the Study:
- To review clinical and molecular features of HGG.
- To explore various chemotherapy application methods in HGG.
- To highlight existing and emerging local drug delivery and targeted therapies for HGG.
Main Methods:
- Literature review of clinical and molecular aspects of HGG.
- Analysis of chemotherapy administration methods, focusing on local delivery.
- Evaluation of targeted therapies for HGG treatment.
Main Results:
- Local drug delivery enhances chemotherapy's pharmacokinetic profile in the tumor region.
- Targeted therapies using local drug delivery can inhibit HGG invasion, proliferation, and recurrence.
- Novel chemical medicines targeting HGG are a key research direction.
Conclusions:
- Local drug delivery is a priority for developing effective HGG therapies.
- Targeted therapies offer a promising approach to combat HGG.
- Advancements in neuro-oncology are crucial for improving outcomes in HGG patients.
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