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Radiotherapy Outcome for Pediatric Pelvic Ewing Sarcoma
Saadiya Javed Khan1, Ather Kazmi2
1Department of Pediatric Oncology, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore.
Summary
Radiotherapy for pelvic Ewing sarcoma (ES) in children and adolescents shows poor local control. Further research into intensity-modulated radiotherapy (IMRT) and compressed chemotherapy cycles is recommended for improved outcomes.
Area of Science:
- Pediatric Oncology
- Radiation Oncology
- Skeletal Tumors
Background:
- Pelvic Ewing sarcoma (ES) presents a significant challenge in pediatric oncology.
- Effective local control strategies are crucial for improving patient survival and reducing recurrence rates.
Purpose of the Study:
- To assess the outcomes of radiotherapy in patients with primary pelvic Ewing sarcoma (ES).
- To identify factors influencing local control and survival in this patient cohort.
Main Methods:
- A case series study was conducted at Shaukat Khanum Memorial Cancer Hospital from January 2010 to October 2015.
- Patients with primary pelvic ES treated with radiotherapy and the EuroEwing-99 chemotherapy protocol were analyzed.
- Tumor volume, local relapse, and distant metastases were key parameters evaluated.
Main Results:
- The study included 13 pediatric and adolescent patients with pelvic ES, with a median age of 15 years.
- Over 50% of patients had large tumor volumes (>400ml).
- A high rate of local relapse (61.5%) and combined local-distant metastases (38.5%) was observed.
Conclusions:
- Radiotherapy for primary pelvic Ewing sarcoma demonstrates suboptimal local control and overall survival in pediatric and adolescent populations.
- Intensity-modulated radiotherapy (IMRT) offers potential for dose escalation.
- Compressed chemotherapy cycles warrant investigation to enhance treatment efficacy in the local setting.
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