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Updated: Feb 9, 2026

Electrophysiological Recording of The Central Nervous System Activity of Third-Instar Drosophila Melanogaster
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Electrophysiological Recording of The Central Nervous System Activity of Third-Instar Drosophila Melanogaster

Published on: November 21, 2018

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CORL Expression in the Drosophila Central Nervous System Is Regulated by Stage Specific Interactions of Intertwined

Nancy L Tran1, Norma T Takaesu1, Elizabeth F Cornell1

  • 1School of Life Sciences, Arizona State University, Tempe AZ 85287-4501.

G3 (Bethesda, Md.)
|June 1, 2018
PubMed

Insights

Drosophila CORL (dCORL) is regulated by complex interactions in the central nervous system. dCORL’s presence in insulin-producing cells suggests a role in modulating insulin signaling for neuronal activation.

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Genetics

Background:

  • CORL proteins (SKOR in mice, Fussel in humans) are CNS-specific, related to Sno/Ski oncogenes.
  • Their developmental and homeostatic roles are largely unknown.
  • Previous work showed Drosophila CORL (dCORL) functions between Activin receptor and Ecdysone Receptor-B1 (EcR-B1) activation in larval mushroom body neurons.

Purpose of the Study:

  • To elucidate the regulation and function of dCORL in the central nervous system (CNS).
  • To investigate dCORL's role in developmental processes and homeostasis.
  • To explore potential non-autonomous functions of dCORL in neuronal signaling.

Main Methods:

  • Generation of reporter genes to study dCORL regulation.
  • Examination of embryonic and larval CNS expression patterns.
  • Analysis of dCORL coexpression with neuronal markers (Elav) and transcription factors (Drifter).

Main Results:

  • dCORL expression is regulated by stage-specific interactions of activators and repressors.
  • A reporter gene (AH.lacZ) reflected dCORL brain expression but not in EcR-B1 neurons.
  • dCORL was coexpressed with Elav and Drifter in insulin-producing cells (dILP2) of the pars intercerebralis.

Conclusions:

  • dCORL exhibits complex, stage-specific transcriptional regulation in the CNS.
  • dCORL's presence in insulin-producing cells suggests a non-autonomous role in regulating EcR-B1 activation via insulin signaling.
  • Conserved functions in mammals are suggested for CORL/SKOR/Fussel proteins, potentially involving complex regulation and insulin signaling.
Keywords:
DrifterFussel/SKORdILP2pars intercerebralistwin of eyeless

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