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Updated: Feb 9, 2026

Isolation and Expansion of Human Glioblastoma Multiforme Tumor Cells Using the Neurosphere Assay
09:24

Isolation and Expansion of Human Glioblastoma Multiforme Tumor Cells Using the Neurosphere Assay

Published on: October 30, 2011

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Specifically Targeted Electromagnetic Fields Arrest Proliferation of Glioblastoma Multiforme U-87 Cells in Culture

Carmen J Narvaez1,2, Samantha K Mall2,3, Aaron Fountain1,3,4

  • 1Center for Functional Genomics, Rensselaer, NY, U.S.A.

Anticancer Research
|June 1, 2018
PubMed
Abstract

Insights

Ultra-low intensity electromagnetic fields show promise in treating glioblastoma multiforme. This novel, non-invasive radiation therapy significantly inhibited glioblastoma cell growth and increased cell death without side-effects.

Area of Science:

  • Oncology
  • Biophysics
  • Molecular Biology

Background:

  • Glioblastoma multiforme is an aggressive brain tumor with poor prognosis and high treatment morbidity.
  • Current treatments offer limited survival benefits, necessitating novel therapeutic strategies.
  • Ultra-low intensity electromagnetic fields (EMFs) offer a non-invasive approach with potential biological interactions.

Purpose of the Study:

  • To investigate the efficacy of a novel non-ionizing radiation application in inhibiting glioblastoma multiforme cell proliferation.
  • To explore the potential of EMFs as a non-invasive therapeutic modality for glioblastoma.

Main Methods:

  • U-87 MG glioblastoma cells were exposed to a specifically tuned electromagnetic field for 54 hours.
  • The EMF was designed to interact simultaneously with DNA/RNA oligonucleotides (mutated alpha-kinase 2 gene/Hsa-miR-381-5p) and proteins (HSP70/CHI3L1).

Main Results:

  • Continuous EMF exposure resulted in significant inhibition of glioblastoma cell growth.
  • A concurrent increase in glioblastoma cell death was observed following EMF exposure.

Conclusions:

  • The studied technology induces glioblastoma cell death via novel, non-cytotoxic mechanisms.
  • This approach is unlikely to cause adverse side-effects in patients and may be customized for individual tumors.
  • This EMF-based therapy represents a potential advancement in personalized medicine for glioblastoma treatment.
Keywords:
DNA FragmentationRGFields™apoptosiscell cycleresonancetranscriptome

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