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Fusobacterium necrophorum Subsp. funduliforme in Tonsils from Various Patient Populations in Japan

Kayoko Hayakawa1, Maki Nagashima1, Kaichi Ohta2

  • 1Disease Control and Prevention Center, National Center for Global Health and Medicine.

Japanese Journal of Infectious Diseases
|June 1, 2018
PubMed

Insights

Fusobacterium necrophorum subsp. funduliforme (FNSF) was frequently found in tonsils regardless of indication for tonsillectomy. Its constant presence may not be linked to recurrent pharyngotonsillitis in adults.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Otolaryngology

Background:

  • Fusobacterium necrophorum is increasingly implicated in throat infections like tonsillopharyngitis and peritonsillar abscess.
  • Fusobacterium necrophorum subsp. funduliforme (FNSF) is recognized as a significant human pathogen within this species.

Purpose of the Study:

  • To investigate the prevalence and epidemiological significance of FNSF in adult tonsils.
  • To determine if FNSF presence correlates with indications for tonsillectomy, particularly infectious versus non-infectious causes.

Main Methods:

  • Prospective study of adult patients undergoing elective tonsillectomy (n=32) between October 2014 and November 2015.
  • Tonsil tissue samples were analyzed using aerobic and anaerobic cultures.
  • Detection of FNSF was confirmed via PCR targeting gyrB primers and 16S rRNA genes.

Main Results:

  • FNSF was detected in tonsil samples from the enrolled patients.
  • The prevalence of FNSF, identified by culture or PCR, showed no significant difference between patients with infectious and non-infectious indications for tonsillectomy.
  • These findings suggest FNSF is consistently present in tonsils.

Conclusions:

  • The study indicates a high prevalence of FNSF in adult tonsils, irrespective of the reason for tonsillectomy.
  • The constant presence of FNSF may not be directly associated with the pathogenesis of recurrent pharyngotonsillitis.
Keywords:
Fusobacterium necrophorum subsp. funduliformepharyngotonsillitisrecurrent pharyngotonsillitistonsil

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