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Updated: Feb 9, 2026

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke

Published on: January 18, 2018

Clozapine Intoxication Mimicking Acute Stroke.

Jacob A Lebin¹, Joshua D Villarreal², Betty C Chen¹

¹University of Washington, Department of Emergency Medicine, Seattle, Washington.

Clinical Practice and Cases in Emergency Medicine

|June 1, 2018

Summary

Accidental clozapine intoxication can mimic stroke and cause seizures in patients. Early identification is crucial to prevent harm from this rare antipsychotic overdose.

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Area of Science:

Pharmacology
Neurology
Emergency Medicine

Background:

Clozapine is an atypical antipsychotic used for treatment-resistant schizophrenia.
Its use is limited by risks of hematologic, cardiovascular, and neurologic adverse effects.
Overdose reports are infrequent.

Observation:

A clozapine-naïve patient experienced accidental acute intoxication.
Initial symptoms mimicked an acute stroke.
The patient later developed status epilepticus.

Findings:

Acute clozapine intoxication can present with diverse and severe neurologic symptoms.
Symptoms may initially resemble other critical conditions like stroke.
Status epilepticus is a potential complication of clozapine overdose.

Implications:

Accurate and timely diagnosis of clozapine intoxication is vital in emergency settings.
Emergency departments must consider clozapine overdose in patients with unexplained neurologic deterioration.
Failure to identify clozapine toxicity can lead to significant iatrogenic harm.