Corticotropin-releasing factor--induced adrenocorticotropic hormone release in the sheep fetus: blockade by cortisol

Related Experiment Video

Updated: Aug 22, 2026

Instrumentation of Near-term Fetal Sheep for Multivariate Chronic Non-anesthetized Recordings
14:40

Instrumentation of Near-term Fetal Sheep for Multivariate Chronic Non-anesthetized Recordings

Published on: October 25, 2015

J C Rose, B Y Hargrave, P M Dix

    American Journal of Obstetrics and Gynecology
    |April 15, 1985
    PubMed

    More Related Videos

    Fecal Glucocorticoid Analysis: Non-invasive Adrenal Monitoring in Equids08:02

    Fecal Glucocorticoid Analysis: Non-invasive Adrenal Monitoring in Equids

    Published on: April 25, 2016

    In Vivo Real-Time Study of Drug Effects on Carotid Blood Flow in the Ovine Fetus11:59

    In Vivo Real-Time Study of Drug Effects on Carotid Blood Flow in the Ovine Fetus

    Published on: April 28, 2023

    Related Concept Videos

    Hypothalamic-Pituitary Axis01:37

    Hypothalamic-Pituitary Axis

    The response to stress—be it physical or psychological, acute or chronic—involves activation of the Hypothalamic-Pituitary-Adrenal (HPA) axis. The HPA axis is part of the neuroendocrine system because it involves both neuronal and hormonal communication. Its function is to regulate homeostatic systems—metabolic, cardiovascular, and immune—providing the necessary means to respond to a stressor.
    Hormonal Regulation01:33

    Hormonal Regulation

    The renin-aldosterone system is an endocrine system which guides the renal absorption of water and electrolytes, thus managing blood pressure and osmoregulation. Activation of the system begins in the kidneys with a small cluster of cells adjacent to the afferent and efferent blood vessels of the renal corpuscle. As the nephrons are filtering blood, juxtaglomerular cells monitor blood pressure. If they detect a decrease in pressure, they release the hormone renin into the bloodstream.
    Regulation of Hormone Secretion01:19

    Regulation of Hormone Secretion

    Regulation of hormone secretion is a finely tuned orchestration driven by various types of stimuli, encompassing neural, humoral, and hormonal signals. Environmental cues instigate neural stimuli, where action potentials traverse nerve fibers to reach their designated targets. An illustrative scenario is the body's response to stress, wherein the sympathetic nervous system releases epinephrine from the adrenal glands, inducing the well-known 'fight or flight' reaction.
    Humoral stimuli,...
    Hormones of the Adrenal Glands01:31

    Hormones of the Adrenal Glands

    Adrenal hormones play a pivotal role in maintaining the body's electrolyte balance and orchestrating responses to stress, showcasing the intricate functions of the adrenal cortex and medulla.
    The adrenal cortex, a powerhouse of hormone synthesis, generates over two dozen corticosteroid hormones. The zona glomerulosa produces mineralocorticoids, exemplified by aldosterone, influencing the electrolyte composition of body fluids. The synthesis of glucocorticoids such as cortisol and corticosterone...
    Cushing Syndrome I: Introduction01:26

    Cushing Syndrome I: Introduction

    Cushing syndrome refers to the collection of clinical manifestations that arise when tissues are exposed to excessive amounts of cortisol or cortisol-like medications over an extended period. Cortisol, a glucocorticoid produced by the adrenal cortex, regulates metabolism, immune responses, and the body’s adaptation to stress. When its concentration remains chronically elevated, these physiological pathways become dysregulated, resulting in the characteristic features of the syndrome.Exogenous...
    Cushing Syndrome II: Pathophysiology01:19

    Cushing Syndrome II: Pathophysiology

    Cortisol production is normally governed by the hypothalamic–pituitary–adrenal (HPA) axis, which maintains hormonal balance through tightly regulated feedback mechanisms. Disruption of this regulatory system is central to the development of Cushing syndrome, whether the excess cortisol originates from external medications or internal pathology. Persistent cortisol elevation alters metabolism, immune function, and endocrine signaling, producing the characteristic clinical features of the...