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[Vitamin D3 poisoning and irreversible sequela].
Anales Espanoles De Pediatria
|February 1, 1985
Summary
Vitamin D intoxication in children, often due to medical over-dosage, can cause severe symptoms. While hypercalcemia is treatable, prolonged over-dosage leads to permanent damage, including chronic renal failure.
Area of Science:
- Pediatric Endocrinology
- Clinical Toxicology
Context:
- Vitamin D intoxication is a serious condition in children.
- Over-dosage can stem from medical prescriptions or parental administration.
Purpose:
- To review clinical outcomes and sequelae in children with vitamin D intoxication.
- To analyze the relationship between dosage, duration, and clinical presentation.
Summary:
- This study reviewed 24 children with vitamin D intoxication, noting that 66.6% resulted from medical over-prescription.
- Clinical symptoms correlated with the daily dose, while long-term damage depended on the duration of over-dosage.
- Hypercalcemia was corrected in 81% within a month using diet, corticosteroids, and furosemide.
Impact:
- Two children died during the acute phase.
- 22.7% of patients experienced permanent damage, including chronic renal failure and intellectual disability.
- Highlights the critical need for careful vitamin D dosage monitoring in pediatric care.