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Microdialysis of Ethanol During Operant Ethanol Self-administration and Ethanol Determination by Gas Chromatography

Microdialysis of Ethanol During Operant Ethanol Self-administration and Ethanol Determination by Gas Chromatography

Published on: September 5, 2012

Lamotrigine ethanol monosolvate.

Charlie L Hall¹, Jason Potticary¹, Hazel A Sparkes¹

¹School of Chemistry, University of Bristol, Cantock's Close, Bristol, England BS8 1TS, England.

Acta Crystallographica. Section E, Crystallographic Communications

|June 1, 2018

Summary

This summary is machine-generated.

Researchers crystallized lamotrigine, an epilepsy and psychiatric drug, as an ethanol solvate. The crystal structure reveals specific hydrogen bonding patterns forming dimers and tape motifs, with disordered ethanol molecules.

Keywords:

crystal structure ethanolate lamotrigine

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Area of Science:

Crystallography
Solid-state chemistry
Pharmaceutical science

Background:

Lamotrigine is a key pharmaceutical ingredient for treating epilepsy and psychiatric conditions.
Understanding the solid-state structure of active pharmaceutical ingredients (APIs) is crucial for drug formulation and stability.
Solvate formation can significantly impact the physical and chemical properties of APIs.

Purpose of the Study:

To elucidate the crystal structure of a lamotrigine ethanol solvate.
To investigate the intermolecular interactions and packing arrangements within the crystal lattice.
To characterize the stoichiometry and guest molecule behavior in the solvate.

Main Methods:

Single crystal X-ray diffraction was employed to determine the molecular and crystal structure.
Slow evaporation of a saturated solution in anhydrous ethanol was used for crystal growth.
Analysis of hydrogen bonding networks and guest molecule disorder was performed.

Main Results:

A 1:1 ethanol solvate of lamotrigine (C9H7Cl2N5·C2H5OH) was successfully synthesized and characterized.
Lamotrigine molecules form dimers via N-H⋯N hydrogen bonds, which further assemble into tape motifs.
The ethanol molecule's ethyl group exhibits positional disorder within the crystal lattice.

Conclusions:

The study provides detailed insights into the crystal engineering of lamotrigine ethanol solvate.
The identified hydrogen bonding patterns are critical for understanding lamotrigine's solid-state behavior.
The observed disorder in the ethanol guest molecule highlights the complexity of solvate formation.