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Updated: Feb 9, 2026

Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas
Published on: February 28, 2019
A Case of Invasive Sinonasal Carcinosarcoma: The Importance of Early Detection
Jason Yuen1, Vinay Varadarajan2, Marios Stavrakas2
1South West Neurosurgery Centre, Derriford Hospital, Plymouth PL6 8DH, UK.
Abstract:
Sinonasal carcinosarcomas represent rare neoplasms, with aggressive character and unfavourable prognosis. We present a case of extensive sinonasal carcinosarcoma extending into the anterior cranial fossa and into the orbit and also a review of the current international literature regarding this rare yet aggressive neoplasm. There is currently a lack of specific guidelines on the optimal management of sinonasal carcinosarcoma and the treatment represents a challenge for the clinician. The key message that we would like to disseminate to our colleagues is the importance of suspicion and early detection, as well as the necessity to adopt a holistic approach when counselling patients.
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