Related Experiment Video

Updated: Feb 9, 2026

Induction of Atherosclerotic Plaques Through Activation of Mineralocorticoid Receptors in Apolipoprotein E-deficient Mice
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Induction of Atherosclerotic Plaques Through Activation of Mineralocorticoid Receptors in Apolipoprotein E-deficient Mice

Published on: September 26, 2018

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Mineralocorticoid receptor signaling affects therapeutic effect of enzalutamide

Masaki Shiota1, Naohiro Fujimoto2, Katuyoshi Higashijima2

  • 1Department of Urology,, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

The Prostate
|June 1, 2018
PubMed
Abstract

Insights

Corticosteroids impact enzalutamide treatment for prostate cancer. Dexamethasone reduces effectiveness, while mineralocorticoid receptor (MR) activation may overcome resistance to androgen receptor (AR)-targeting therapies.

Area of Science:

  • Oncology
  • Endocrinology
  • Pharmacology

Background:

  • Corticosteroids are used in prostate cancer treatment.
  • Their interaction with enzalutamide, an androgen receptor (AR) targeting therapy, is not fully understood.

Purpose of the Study:

  • To investigate the functional and clinical effects of corticosteroids on steroid receptors during enzalutamide treatment.
  • To determine the impact of corticosteroids on AR-targeting therapy efficacy.

Main Methods:

  • Studied 86 men treated with enzalutamide, analyzing concomitant corticosteroid use.
  • Assessed prostate cancer cell sensitivity to agents via cytotoxicity assays.
  • Evaluated gene expression using quantitative real-time polymerase chain reaction.

Main Results:

  • Dexamethasone significantly reduced enzalutamide's therapeutic effect, increasing cellular resistance.
  • Prednisolone and aldosterone decreased enzalutamide resistance.
  • Mineralocorticoid receptor (MR) knockdown enhanced AR signaling and enzalutamide resistance.

Conclusions:

  • Mineralocorticoid receptor (MR) plays a key role in resistance to AR-targeting therapies.
  • Activating MR signaling could potentially overcome treatment resistance.
Keywords:
androgen receptorenzalutamideglucocorticoid receptormineralocorticoid receptorprostate cancer

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